Serotonin and emotion regulation: the impact of tryptophan depletion on emotional experience, neural and autonomic activity.

The involvement of serotonin in emotion and psychopathology has been extensively examined. Studies using acute tryptophan depletion (ATD) have found limited effects on mood and aggression, and one of the explanations suggests that serotonin may be involved in higher-order functions, such as emotion regulation. However, there is very limited evidence for this hypothesis.

Safety of Vaccination within First Year of Life-The Experience of One General Medicine Center.

Vaccines represent an important preventive strategy in paediatric populations, but the rate of vaccination has been constantly declining in the last decade. Concerns about vaccines' safety represent one of the main causes of vaccine hesitancy among parents. The aim of this study was the analysis of the immediate adverse reactions induced by vaccines included in the national program of immunization for the first year of life.

Blockchain and Demand Response: Zero-Knowledge Proofs for Energy Transactions Privacy.

Nowadays, the adoption of demand response programs is still lagging due to the prosumers' lack of awareness, fear of losing control and privacy of energy data, etc. Programs decentralization, by adopting promising technologies such as blockchain, may bring significant advantages in terms of transparency, openness, improved control, and increased active participation of prosumers. Nevertheless, even though in general the transparency of the public blockchain is a desirable feature in the energy domain, the prosumer energy data is sensitive and rather private, thus, a privacy-preserving solution is required.

Overview of the pediatric healthcare system in Romania.

Until 1989, Romania was one of the countries of the communist bloc in Europe and its healthcare system was characterized by centralized planning and severe underfunding, with low performance and low quality healthcare. Since 1998, Romania replaced the Semashko model with a social health insurance system, highly centralized under the management of the Ministry of Health as the central administrative authority. After joining the European Union, quality of life increased in our country and there were efforts to improve the quality of healthcare, including pediatric and neonatal care.

Smart Environments and Social Robots for Age-Friendly Integrated Care Services.

The world is facing major societal challenges because of an aging population that is putting increasing pressure on the sustainability of care. While demand for care and social services is steadily increasing, the supply is constrained by the decreasing workforce. The development of smart, physical, social and age-friendly environments is identified by World Health Organization (WHO) as a key intervention point for enabling older adults, enabling them to remain as much possible in their residences, delay institutionalization, and ultimately, improve quality of life.

A Fog Computing enabled Virtual Power Plant Model for Delivery of Frequency Restoration Reserve Services.

Nowadays, centralized energy grid systems are transitioning towards more decentralized systems driven by the need for efficient local integration of new deployed small scale renewable energy sources. The high limits for accessing the energy markets and also for the delivery of ancillary services act as a barrier for small scale prosumers participation forcing the implementation of new cooperative business models at the local level. This paper is proposing a fog computing infrastructure for the local management of energy systems and the creation of coalitions of prosumers able to provide ancillary services to the grid.

Blockchain-Based Scalable and Tamper-Evident Solution for Registering Energy Data.

Nowadays, it has been recognized that blockchain can provide the technological infrastructure for developing decentralized, secure, and reliable smart energy grid management systems. However, an open issue that slows the adoption of blockchain technology in the energy sector is the low scalability and high processing overhead when dealing with the real-time energy data collected by smart energy meters. Thus, in this paper, we propose a scalable second tier solution which combines the blockchain ledger with distributed queuing systems and NoSQL (Not Only SQL database) databases to allow the registration of energy transactions less frequently on the chain without losing the tamper-evident benefits brought by the blockchain technology.

Blockchain Based Decentralized Management of Demand Response Programs in Smart Energy Grids.

In this paper, we investigate the use of decentralized blockchain mechanisms for delivering transparent, secure, reliable, and timely energy flexibility, under the form of adaptation of energy demand profiles of Distributed Energy Prosumers, to all the stakeholders involved in the flexibility markets (Distribution System Operators primarily, retailers, aggregators, etc.). In our approach, a blockchain based distributed ledger stores in a tamper proof manner the energy prosumption information collected from Internet of Things smart metering devices, while self-enforcing smart contracts programmatically define the expected energy flexibility at the level of each prosumer, the associated rewards or penalties, and the rules for balancing the energy demand with the energy production at grid level.

Obesity is a concern for bone health with aging.

Accumulating evidence supports a complex relationship between adiposity and osteoporosis in overweight/obese individuals, with local interactions and endocrine regulation by adipose tissue on bone metabolism and fracture risk in elderly populations. This review was conducted to summarize existing evidence to test the hypothesis that obesity is a risk factor for bone health in aging individuals. Mechanisms by which obesity adversely affects bone health are believed to be multiple, such as an alteration of bone-regulating hormones, inflammation, oxidative stress, the endocannabinoid system, that affect bone cell metabolism are discussed.

VITAMIN D-BINDING PROTEIN IN HEALTHY PRE- AND POSTMENOPAUSAL WOMEN: RELATIONSHIP WITH ESTRADIOL CONCENTRATIONS.

Objective: To examine the relationship between endogenous serum estradiol and vitamin D-binding protein (DBP) and total, free, and bioavailable 25-hydroxyvitamin D (25OHD) concentrations in pre- and postmenopausal women.

Methods: In 165 healthy women (ages, 26 to 75 years) not taking any form of exogenous estrogen, the serum concentrations of estradiol, 25OHD, DBP, parathyroid hormone, and albumin were measured. Free and bioavailable 25OHD (free + albumin-bound) levels were calculated from total 25OHD, DBP, and serum albumin levels.

Moderate weight loss in obese and overweight men preserves bone quality.

Background: Weight loss (WL) negatively affects bone mineral density (BMD) in older populations and has specifically been shown in women.

Objective: In this prospective controlled trial, we examined variables of bone quality and endocrine changes after intentional WL in men.

Design: Thirty-eight overweight and obese [mean ± SD body mass index (in kg/m²): 31.

[Quality of life in children with bronchial asthma and allergic rhinitis].

The quality of life is a subjective parameter that evaluates the impact of asthma on daily life of the child. The authors evaluated the evolution of the quality of life score in children with persistent asthma and analyzed the impact of association of allergic rhinitis on this parameter. The evaluation of the quality of life was based on a questionnaire with 23 items (PAQLQ), which was applied on 54 children with asthma (35 of them having rhinitis allergic associated to asthma).