Publications by authors named "Claudia Pacini"
Article Synopsis
- - The study investigates the role of noncoding DNA regions, known as cis-regulatory elements (CRE), in the evolution of hormone-dependent breast cancer and its resistance to endocrine therapy, explaining about 40% of cancer relapses.
- - Using functional genomics and CRISPRi techniques, the researchers analyze how these CREs influence cancer cell behavior, particularly in relation to dormancy and therapy resistance.
- - The findings suggest that while dormant cancer cells are less susceptible to treatment changes, they develop temporary vulnerabilities that could be targeted to prevent the emergence of resistant cancer cells.
Genomic analysis of a metronidazole resistant H. bizzozeronii strain revealed a frame length extension of the oxygen-insensitive NAD(P)H-nitroreductase HBZC1_00960 (RdxA), associated with the disruption of the C-terminal cysteine-containing conserved region (IACLXALGK). This was the result of the extension (from C8 to C9) of a simple sequence cytosine repeat (SSCR) located in the 3' of the gene.
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