Publications by authors named "Claudia P Schifone"
Endothelium damage triggers the multimeric protein von Willebrand factor (VWF) release and subsequent binding to platelets, which are recruited at sites of vascular injury. A complex and fragile equilibrium between circulating levels of von Willebrand factor and its metalloprotease, ADAMTS13, is responsible for the hemostatic balance. However, the presence of autoantibodies targeting ADAMTS13 results in an increase in von Willebrand factor, mainly in its ultra-large multimers.
View Article and Find Full Text PDFImmunomodulatory drugs (IMiDs) are analogs of thalidomide. They have immunomodulatory, antiangiogenic and proapoptotic properties and exert a role in regulating the tumor microenvironment. Recently IMiDs have been investigated for their pleiotropic properties and their therapeutic applications in both solid tumors (melanoma, prostate carcinoma and differentiated thyroid cancer) and hematological malignancies.
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- Multiple Myeloma (MM) predominantly develops in the bone marrow, where the surrounding microenvironment is crucial for the growth and survival of plasma cells.
- The study identified a specific type of bone marrow cell, known as Mesenchymal Progenitor Cells (MPCs), which showed altered behavior in MM, particularly a preference for angiogenesis over musculoskeletal tissue formation.
- Results indicate that MM-derived MPCs exhibit prolonged angiogenic sprouting, highlighting their potential role in contributing to the angiogenic changes associated with MM, especially during active disease.