Publications by authors named "Claudia Olive Roig"
Int J Mol Sci
January 2023
Article Synopsis
- mLOY (mosaic loss of chromosome Y) is linked to aging and has associations with Alzheimer's disease (AD), but its influence can be misinterpreted due to age factors in studies.
- Using Mendelian randomization, researchers created a polygenic risk score (mloy-PRS) that accounts for age, revealing a significant increase in mLOY risk that is independent of age.
- Results indicate that higher genetic risk for mLOY correlates with quicker AD progression in men with mild cognitive impairment, while showing no impact on women, and suggesting mLOY plays a role in the development of AD.
