Prevention of type 2 diabetes in obese at-risk subjects: a systematic review and meta-analysis.

Different intervention strategies can prevent new cases of type 2 diabetes (T2DM) in obese subjects. The present systematic review and meta-analysis evaluates the effectiveness of different strategies in prevention of type 2 diabetes in obese subjects. Studies were grouped into five different strategies: (1) physical activity ± diet; (2) anti-diabetic drugs (glitazones, metformin, glinides, alfa-glucosidase inhibitors); (3) antihypertensive drugs (ACE inhibitors, ARB); (4) weight loss-promoting drugs and lipid-lowering drugs (orlistat, bezafibrate, phentermine/topiramate controlled release); and (5) bariatric surgery.

Effect of weight loss on sympatho-vagal balance in subjects with grade-3 obesity: restrictive surgery versus hypocaloric diet.

Few and mostly uncontrolled studies indicate that weight loss improves heart rate variability (HRV) in grade-3 obesity. The aim of this study was to compare in grade-3 obesity surgery and hypocaloric diet on clinical and metabolic variables and on autonomic indices of HRV. Twenty-four subjects (body mass index, BMI 45.

Analytical variation in the measurement of serum monoclonal component by capillary electrophoresis.

The amount of serum monoclonal components (MC), and moreover, their variation with time are important factors for differentiating malignancy-associated from benign gammopathies. Capillary electrophoresis (CE) of serum proteins allows better quantitative measurement in comparison to conventional gel-supported electrophoresis. We investigated the analytical variation of CE measurement of serum MC of different sizes: the variation due to integration settings and the analytical variation of the CE procedure were assessed in separate experiments.