Publications by authors named "Claudia Kurreck"
Article Synopsis
- The use of "Wildling mice" with a natural microbiome presents a unique research tool for studying human-like immune systems, but poses challenges for animal husbandry due to their diverse microbial content.
- A specialized facility was created at Charité - Universitätsmedizin Berlin to manage these mice, incorporating unique designs and protocols for hygiene and microbiome containment.
- The study shows that "Wildling mice" develop distinct immune cell populations compared to SPF mice, suggesting that using these mice could improve the relevancy of preclinical findings for human health.
While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Supported through the European Union's Innovative Medicines Initiative, the EQIPD consortium has developed a novel preclinical research quality system that can be applied in both public and private sectors and is free for anyone to use. The EQIPD Quality System was designed to be suited to boost innovation by ensuring the generation of robust and reliable preclinical data while being lean, effective and not becoming a burden that could negatively impact the freedom to explore scientific questions.
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- Audits are seen as a potential solution to ensure the reliability and reproducibility of biomedical research, but they are resource-intensive and often perceived as invasive.
- The study explored various audit approaches in a university neuroscience setting with around 100 participants to identify effective methods for improving research quality.
- Recommendations and resources for implementing these audits were provided, including templates for study design and workflows to enhance the auditing process's effectiveness.
Article Synopsis
- Quality management systems have been effective in various industries, including clinical research.
- These systems can enhance academic research by increasing rigor and reproducibility.
- Adapting these systems to academic settings opens up significant improvement potential for research outcomes.
We here propose the implementation of a simple and effective method to enhance the quality of basic and preclinical academic research: critical incident reporting (CIR). CIR has become a standard in clinical medicine but to our knowledge has never been implemented in the context of academic basic research. We provide a simple, free, open-source software tool for implementing a CIR system in research groups, laboratories, or large institutions (LabCIRS).
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