Publications by authors named "Claudia Irene Emilio de Castro"
Background: Syndromic obesity is an umbrella term used to describe cases where obesity occurs with additional phenotypes. It often arises as part of a distinct genetic syndrome with Prader-Willi syndrome being a classical example. These rare forms of obesity provide a unique source for identifying obesity-related genetic changes.
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- Obesity is a significant global health issue, with increasing evidence pointing to the central nervous system's (CNS) involvement in weight regulation.
- There is a notable connection between genetic factors, such as deficiencies in genes like BDNF and SIM1, and different forms of obesity, especially in those with developmental disorders.
- Analysis of nine patients with obesity and learning disabilities revealed unique genetic alterations (copy number variants) that are likely linked to their conditions and highlight the relationship between obesity and neurodevelopmental challenges.