Publications by authors named "Claudia Hanses"
Article Synopsis
- The study conducted the first genome-wide association study (GWAS) on sporadic Alzheimer's disease (AD) using a sample from Argentina and Chile, involving 539 patients and 854 controls.
- Combining their findings with data from the European Alzheimer and Dementia Biobank (EADB), researchers identified apolipoprotein E ε4 as a significant genetic risk factor and discovered four new loci linked to AD.
- The research highlights the shared genetic factors affecting AD risk across different populations, while also noting that a genetic risk score (GRS) showed diminishing effectiveness with increasing Native American ancestry.
Rare coding variants in TREM2, PLCG2, and ABI3 were recently associated with the susceptibility to Alzheimer's disease (AD) in Caucasians. Frequencies and AD-associated effects of variants differ across ethnicities. To start filling the gap on AD genetics in South America and assess the impact of these variants across ethnicity, we studied these variants in Argentinian population in association with ancestry.
View Article and Find Full Text PDFDNA sequence variants of the FKBP5 gene are associated with unipolar depression.
Int J Neuropsychopharmacol
June 2010
FKBP5 is a glucocorticoid receptor-regulating co-chaperone of hsp-90 and, therefore, is suggested to play a role in the regulation of the hypothalamic-pituitary-adrenocortical system and the pathophysiology of depression. Previously, three studies identified single nucleotide polymorphisms (SNPs) in the FKBP5 gene associated with response to antidepressants, and one study found an association with diagnosis of depression. We selected five markers from the region of interest.
View Article and Find Full Text PDFBackground: Involvement of AKT signaling pathways in schizophrenia has been recently suggested, on the basis of several lines of evidence. In addition to impairment of protein-levels and phosphorylation levels in the pathway, association of DNA sequence variants in the AKT1 gene with schizophrenia has been detected in a family sample.
Methods: We investigated the reported association of DNA sequence variants in the AKT1 gene in a sample of 79 sib-pair families with schizophrenia using the five single nucleotide polymorphisms (SNPs) of the original study and two additional SNPs in the neighborhood of the SNP for which association had been reported.