Publications by authors named "Claudia H M C Oliveira"
Article Synopsis
- - Eosinophilic esophagitis (EoE) is a chronic inflammatory condition that affects eating and quality of life, with existing treatments not fully controlling symptoms for about one-third of patients.
- - A phase 2 study of cendakimab, an anti-IL-13 monoclonal antibody, showed promise in reducing inflammation in EoE patients, leading to a phase 3 study aimed at further evaluating its effectiveness and safety.
- - The phase 3 study will enroll 399 participants to test different dosing regimens of cendakimab against a placebo, focusing on symptoms like difficulty swallowing and histological improvements in eosinophil counts over 48 weeks.
Article Synopsis
- Cendakimab is a treatment that targets and inhibits interleukin-13 (IL-13), which plays a role in the development of atopic dermatitis (AD), and is being studied for its effectiveness in treating this condition compared to a placebo.
- A phase 2 clinical trial involved 221 adult participants with moderate to severe AD who had not responded well to topical treatments, with patients receiving different doses of cendakimab or a placebo from May 2021 to November 2022.
- Results showed that the highest dose of cendakimab (720 mg, once weekly) significantly improved eczema symptoms compared to placebo, while other dosages did not achieve statistical significance, indicating potential for cend
BMS-986263 is a retinoid-conjugated lipid nanoparticle delivering small interfering RNA designed to inhibit synthesis of HSP47 protein, a collagen-specific chaperone protein involved in fibrosis development. This is a phase I, open-label, two-part study evaluating pharmacokinetics and safety of BMS-986263 in participants with hepatic impairment (HI). Part 1 (n = 24) of this study enrolled two cohorts with mild and moderate HI and a separate cohort of age- and body mass index (BMI)-matched participants with normal hepatic function.
View Article and Find Full Text PDFObjective: Verifying the association between glycemic fluctuation and GH response in the glucagon stimulation test. Basal evaluation of growth hormone (GH) has poor diagnostic accuracy due to its pulsatile secretion. GH-stimulation tests are used for an adequate evaluation of somatotrophic axis.
View Article and Find Full Text PDF[Continuous glucose monitoring: a critical appraisal after one year experience].
Arq Bras Endocrinol Metabol
December 2005
Conventional assessment of glycemic control in diabetes mellitus (DM) includes blood glucose attention to glycemia and glycated hemoglobin levels. Recently, we introduced the continuous glucose-monitoring test (CGM) (Medtronic Minimed-CGMS System Gold). Here we describe our experience with this methodology over the year 2004.
View Article and Find Full Text PDFClonidine stimulation test is widely used to evaluate growth hormone secretion. Side effects are somnolence (35%) and arterial hypotension (AH) (5%). The aims of this paper were to evaluate the tolerance to this test regarding blood pressure (BP) decrease, sedation and the efficacy of saline resuscitation to prevent AH.
View Article and Find Full Text PDF