Publications by authors named "Claudia F Silva"

Article Synopsis
  • Genetic and epigenetic factors together influence the progression of complex diseases, particularly in multiple sclerosis (MS).
  • Research was conducted comparing global DNA methylation in lymphocytes and monocytes of MS patients to that of healthy controls, involving 33 patients with relapsing-remitting MS (RRMS) and 5 healthy subjects.
  • The study found distinct DNA methylation patterns based on cell type, noting that monocyte methylation levels were significantly altered after treatment with IFNβ.
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After a stroke in middle cerebral artery territory, there is a high probability of dysfunction of the ventromedial pathways, mainly related with postural control mechanisms such as the anticipatory postural adjustments (APAs). According to neuroanatomical knowledge, these pathways have a predominant ipsilesional disposition, which justifies a bilateral postural control dysfunction, often neglected in rehabilitation. In order to assess this bilateral postural control dysfunction, electromyography activity was assessed in eight post-stroke and 10 healthy individuals in the anterior deltoids, the superior and lower trapezius, and the latissimus dorsi as they reached for a bottle with both upper limbs separately at a self-selected velocity and fast velocity while standing associated with trunk kinematics analysis.

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