Publications by authors named "Claudia Enriquez"
Article Synopsis
- * Research using a mouse model revealed that mast cells (MCs) produce a protein called osteopontin (OPN), which helps inhibit NEPC growth through TNFα production when triggered by NEPC cells.
- * The study identified syndecan-1 (SDC1) as a specific ligand for NEPC that activates this protective pathway, suggesting MCs could be a target for new therapies and SDC1 might serve as a biomarker for early detection of NEPC.
Castration-resistant prostate cancer (CRPC) eventually becomes resistant to androgen receptor pathway inhibitors like enzalutamide. Immunotherapy also fails in CRPC. We propose a new approach to simultaneously revert enzalutamide resistance and rewire anti-tumor immunity.
View Article and Find Full Text PDFData on COVID-19 convalescent plasma (CCP) safety and efficacy in children and young adults are limited. This single-center prospective, open-label trial evaluates CCP safety, neutralizing antibody kinetics, and outcomes in children and young adults with moderate/severe COVID-19 (April 2020-March 2021). A total of 46 subjects received CCP; 43 were included in the safety analysis (SAS); 7.
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- Neuroendocrine differentiation (NED) is a key mechanism that contributes to the resistance of castration-resistant prostate cancer to treatments like androgen deprivation therapies (ADT) and antiandrogen receptor pathway inhibitors (ARPI).
- The study identifies a tumor-stroma interaction where factors like GRP78 and SPARC are involved, suggesting that the surrounding tissue may influence cancer progression under hormone therapy pressure.
- Targeting GRP78 may hold promise as a therapeutic approach, and SPARC downregulation could serve as an early biomarker for detecting tumors that are transitioning to a neuroendocrine state.
Article Synopsis
- Pediatric CNS infections can be life-threatening, making it crucial to identify pathogens for proper treatment and prognosis.
- The study used metagenomic next-generation sequencing (mNGS) to analyze cerebrospinal fluid (CSF) in children with suspected CNS infections, after standard testing was performed.
- The findings showed mNGS identified pathogens in 28.6% of cases, with results available within 38 hours, highlighting its effectiveness for rapid pathogen detection.
Background: Therapies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its life-threatening respiratory infection coronavirus disease 2019 (COVID-19) have been evaluated, including COVID-19 convalescent plasma (CCP). Multiple large reports of CCP treatment in adults exist. Pediatric data on CCP safety and efficacy are limited.
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- Castration-resistant prostate cancers (CRPC) can evolve into lethal neuroendocrine tumors (NEPC), necessitating new treatment options that can target both conditions.
- Research indicates that mast cells (MCs) have a dual role in prostate cancer, prompting interest in targeting both MCs and NEPC cells with existing drugs.
- The antiepileptic drug levetiracetam shows promise by reducing NEPC cell growth and MC activity, leading to potential new therapies for prostate cancer after androgen deprivation.
The assembly and development of the gut microbiome in infants have important consequences for immediate and long-term health. Preterm infants represent an abnormal case for bacterial colonization because of early exposure to bacteria and frequent use of antibiotics. To better understand the assembly of the gut microbiota in preterm infants, fecal samples were collected from 32 very low birth weight preterm infants over the first 6 weeks of life.
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- Immunotherapy, specifically checkpoint inhibitors, shows limited effectiveness in treating prostate cancer due to immune suppression initiated by tumors, particularly by mast cells.
- Research on TRAMP mice (a model for prostate cancer) revealed that mast cells contribute to immune tolerance against the SV40 Large T antigen, reducing the incidence of adenocarcinoma when crossed with mast cell-deficient Kit mice.
- Restoration of T-cell immunity in Kit-TRAMP mice was linked to decreased activity of PMN-MDSCs and the immunoregulatory role of mast cells via CD40L-CD40 interactions, indicating a correlation between high mast cell and PMN-MDSC gene expression with poor clinical outcomes in prostate cancer patients.
Long noncoding RNAs are emerging players in the epigenetic machinery with key roles in development and diseases. Here we uncover a complex network comprising a promoter-associated noncoding RNA (paRNA), microRNA and epigenetic regulators that controls transcription of the tumour suppressor E-cadherin in epithelial cancers. E-cadherin silencing relies on the formation of a complex between the paRNA and microRNA-guided Argonaute 1 that, together, recruit SUV39H1 and induce repressive chromatin modifications in the gene promoter.
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