Alginate-chitosan microcapsules improve vaccine potential of gamma-irradiated Listeria monocytogenes against listeriosis in murine model.

Listeria monocytogenes is a cause of infectious food-borne disease in humans, characterized by neurological manifestations, abortion, and neonatal septicemia. It is intracellular bacterium, which limits the development of protective inactivated vacines. Adjuvants capable of stimulating cellular immune response are important tools for developing novel vaccines against intracellular bacteria.

Host range and susceptibility to Toxoplasma gondii infection in captive neotropical and Old-world primates.

Background: Toxoplasmosis is an important disease affecting captive non-human primates. The goal of this study was to assess the seroprevalence and pathological findings of toxoplasmosis in different species of captive primates.

Methods: Six captive neotropical primates died naturally due to Toxoplasma gondii infection and were necropsied.

N-acetylcysteine reduces amphotericin B deoxycholate nephrotoxicity and improves the outcome of murine cryptococcosis.

Cryptococcosis is a life-threatening fungal infection, and its current treatment is toxic and subject to resistance. Drug repurposing represents an interesting approach to find drugs to reduce the toxicity of antifungals. In this study, we evaluated the combination of N-acetylcysteine (NAC) with amphotericin B (AMB) for the treatment of cryptococcosis.

Essential oils of and have effective antidermatophytic activities and that are antagonised by ketoconazole and potentiated in gold nanospheres.

The investigation of the effects of three essential oils (EOs) from (FRA), (TTO) and (IF), alone and combined with ketoconazole (KTZ), and their functionalised gold nanoparticles (AuNP) against both and indicated that EOs presented activity against . The combination of EOs and KTZ was antagonistic. FRA, TTO, gold nanoparticles capped with (AuNPFRA) and gold nanoparticles capped with (AuNPTTO) presented antidermatophytic activity , with the capacity to reduce fungal burden and to preserve tissue architecture; however, combination treatment with KTZ increased fungal burden and caused tissue damage.