Lipid nanoparticles with improved biopharmaceutical attributes for tuberculosis treatment.

Tuberculosis is a topic of relevance worldwide because of the social and biological factors that triggered the disease and the economic burden on the health-care systems that imply its therapeutic treatment. Challenges to handle these issues include, among others, research on technological breakthroughs modifying the drug regimens to facilitate therapy adherence, avoid mycobacterium drug resistance, and minimize toxic side-effects. Lipid nanoparticles arise as a promising strategy in this respect as deduced from the reported scientific data.

Molecular and physical characterization of octenyl succinic anhydride-modified starches with potential applications in pharmaceutics.

Five commercially available starches modified with octenyl succinic anhydride (OSA) are characterized at a molecular, physicochemical and bulk level providing useful data for designing pharmaceutical products. The degree of substitution (DS) of the starches range from 0.017 to 0.

Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release.

Colloidal systems based on lipids have attracted attention during the last two decades as a delivery method of drugs that are poorly soluble in water. The investigations carried out have focused on the development of different formulations using a wide variety of excipients and active molecules. However, there is no consensus on the structure of the particles in these colloidal systems.

Nanocapsules prepared via nanoprecipitation and emulsification-diffusion methods: comparative study.

The encapsulation of hydrophobic drugs has been widely investigated using mainly oil phase in order to enhance the encapsulation efficiency. However, the effect of the starting materials on the colloidal properties of the final nanocapsules irrespective of the elaboration process has been neglected, and the hydrophobic drug location in the disperse media has not been completely elucidated. Therefore, this paper describes the effect of the oil used in the recipe and the preparation method on the behavior of nanocapsules prepared via nanoprecipitation and via emulsification-diffusion.