Single-centre experience with oral ribavirin in lung transplant recipients with paramyxovirus infections.

Background: Paramyxovirus (PV) infections are increasingly recognized in lung transplant recipients and have been linked to subsequent graft failure and bronchiolitis obliterans syndrome (BOS). Ribavirin represents a possible treatment option although the outcome on graft function and BOS incidence is unknown.

Methods: We analysed outcomes of all PV infections in lung/heart-lung recipients between September 2006 and April 2009 in a single centre.

Effect of adherence to home spirometry on bronchiolitis obliterans and graft survival after lung transplantation.

Background: Patient-controlled home spirometry (HS) after lung transplantation has been shown to be valid and reliable to detect the presence of graft infection and rejection at its earliest onset. Effects of nonadherence to HS on detection of the bronchiolitis obliterans syndrome (BOS) and on graft survival are unknown.

Methods: A 7-year prospective cohort study assessed nonadherence longitudinally using electronic spirometry for 24 months.