Orbitofrontal cortex volume prospectively predicts cannabis and other substance use onset in adolescents.

Background: Identifying neural characteristics that predict cannabis initiation is important for prevention efforts. The orbitofrontal cortex is critical for reward response and may be vulnerable to substance-induced alterations.

Aims: We measured orbitofrontal cortex thickness, surface area, and volume prior to the onset of use to predict cannabis involvement during an average nine-year follow-up.

Earlier Alcohol Use Onset Predicts Poorer Neuropsychological Functioning in Young Adults.

Background: Neurodevelopment may be shaped by environmental factors such as alcohol intake. Over 20% of U.S.