Publications by authors named "Claudia Caronni"
Article Synopsis
- Facioscapulohumeral muscular dystrophy (FSHD) is a common neuromuscular disorder without a cure, linked to increased expression of the transcription factor DUX4, leading to muscle wasting.
- MATR3, a protein associated with ALS and similar conditions, regulates DUX4 by binding to its DNA-binding domain, which helps protect muscle cells from DUX4's harmful effects.
- Research suggests that a shorter form of MATR3 is effective in blocking DUX4 toxicity, positioning MATR3 as a potential target for FSHD treatment development.
