Enhancing Proteotoxic Stress in Leiomyosarcoma Cells Triggers Mitochondrial Dysfunctions, Cell Death, and Antitumor Activity .

Leiomyosarcomas are rare and aggressive tumors characterized by a complex karyotype. Surgical resection with or without radiotherapy and chemotherapy is the standard curative treatment. Unfortunately, a high percentage of leiomyosarcomas recurs and metastasizes.

[Diagnostic accuracy in 267 patients with suspected appendicitis: a retrospective study].

Despite what is commonly believed, the diagnosis of acute appendicitis is not always easy. Proof of this is the high rate of negative appendicectomies performed yearly in any surgery unit. "Unnecessary" operations involve a huge waste of resources and are sometimes associated with severe complications.

[Wandering spleen with torsion of the pedicle. A case report and review of the literature].

Congenital deficiency or acquired laxity of the suspensory ligaments, that usually hold the spleen in place in its compartment, may result in extreme splenic mobility. Consequently, this mobility predisposes to torsion of the elongated splenic vascular pedicle creating a situation of acute abdomen due to haemorrhagic infarction. Various imaging modalities for diagnosing the wandering spleen such as ultrasonography, CT scan, MR-angiography, nuclear scan and arteriography are of great value both in the asymptomatic condition and in acute abdomen.