In silico analysis of molecular mimicry between human aquaporin 3, aquaporin and aquaporins from allergic sources.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition that has a significant impact on quality of life. The immune response and allergy symptoms in AD are triggered by the recognition of specific allergens by IgE antibodies. Cross-reactivity can lead to auto-IgE responses, potentially worsening AD symptoms.

[In silico analysis of molecular mimicry between human aquaporin 3, Aspergillus fumigatus aquaporin and aquaporins from allergic sources].

Objective: Conduct an in-silico assessment of potential molecular mimicry between human aquaporins, , and diverse allergenic sources.

Methods: Amino acid sequences of human AQP3 and aquaporin were compared through multiple alignments with 25 aquaporins from diverse allergenic sources. Phylogenetic analysis and homology-based modeling were executed, and the ElliPro server predicted conserved antigenic regions on 3D structures.