Publications by authors named "Claudia A Lipschultz"
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Synopsis of recent research by authors named "Claudia A Lipschultz"
- Claudia A Lipschultz's research focuses on the molecular dynamics and energetics of antibody-antigen interactions, utilizing advanced techniques such as NMR, molecular dynamics simulations, and X-ray crystallography to investigate binding affinities and structural properties of antibodies.
- Key findings reveal that specific modifications, like fluorine labeling and light chain somatic mutations, significantly influence the thermodynamics and dynamics of antibody binding, affecting both specificity and cross-reactivity among closely related antibodies against hen egg white lysozyme.
- The studies highlight the importance of electrostatic properties and temperature effects in regulating antibody binding kinetics, providing insights that could inform therapeutic antibody design and clinical applications related to neurofibromatosis type 1 and glioma treatments.
