Publications by authors named "Claude Speeg-Schatz"
Purpose: To report the effect of internal limiting membrane (ILM) peeling prior to Voretigen Neparvovec-ryzl (VN) subretinal injection on focal chorioretinal atrophy development in patients presenting with RPE65-mediated Leber congenital amaurosis (LCA).
Design: Retrospective case series.
Methods: Three patients who underwent bilateral subretinal VN injection for RPE65-mediated LCA were followed up for 18-24 months.
Purpose: To determine the long-term microvascular alterations associated with macular cystic changes after retinal detachment surgery with silicone oil tamponade.
Methods: The results of two optical coherence tomography angiographies performed at 11 months and 38 months after silicone removal were retrospectively analyzed for 30 eyes. The data were compared between both measurements and between eyes with macular cysts (MC+) and without macular cysts (MC-).
Purpose: To report two cases of persistent macular edema caused by the exudation of diabetic telangiectatic capillaries (TelCaps), which have been successfully treated with photodynamic therapy (PDT).
Methods: Review of data from two patients suffering from persistent macular edema caused by parafoveolar TelCaps. In both cases, conventional laser was impossible because TelCaps were to close from foveal center.
Objective: To quantify changes in ductions following nasal transposition of the split lateral rectus muscle (NTSLR) for treating third nerve palsy.
Design: Retrospective cohort study.
Participants: A single eye from each patient with third nerve palsy treated with NTSLR with ocular motility measurements.
Article Synopsis
- Amblyopia is a significant public health issue that requires effective visual acuity assessments, but many smartphone apps lack scientific validation for medical use.
- A study involving 100 children aged 3 to 8 compared the eMOVA test, a tablet-based assessment, to a conventional test (Rossano-Weiss test) to evaluate its effectiveness and usability.
- Although the eMOVA test slightly overestimated visual acuity, it was well-received by children and parents, proving to be a reliable and convenient tool for pediatric eye examinations in hospital settings.
Purpose: The purpose of the study was to assess OCT-angiography (OCT-A) contribution for choroidal neovascularization (CNV) detection, with respect to multimodal imaging (MMI) modality (including OCT, fluorescein angiography (FFA), and indocyanine green angiography [ICG]), in a real-life consultation practice.
Methods: Data of all consecutive patients undergoing OCT-A examination for CNV suspicion were collected between September 2017 and September 2019 at Strasbourg University Hospital, France. Only eyes which had anti-VEGF injection in the last 3 months were excluded.
"Screening for visual disturbances in children.Vision screening in children is a public health concern, as untreated visual disorders may have irreversible consequences, as well as an important social, scholar, and financial impact. Moreover, most of these disturbances such as refractive errors or strabismus can easily be corrected.
View Article and Find Full Text PDFPurpose: To determine the mechanism behind macular bulge height increase in eyes with dome-shaped macula (DSM).
Design: Retrospective, observational case series.
Methods: Eyes presenting with DSM followed up for a minimum of 1 year were examined using ocular biometry and spectral-domain optical coherence tomography at baseline and at end of follow-up.
Article Synopsis
- - The study aimed to validate a touchpad visual acuity test for children by comparing it to traditional tests, using a cohort of 101 pediatric patients aged 3 to 10 in Strasbourg, France.
- - Results showed strong correlations between the touchpad app and standard tests for monocular and binocular vision, with low measurement errors and no significant differences in results.
- - The touchpad application proved to be an effective tool for screening visual impairments in children, demonstrating good sensitivity (92%) and specificity (80%) for identifying amblyopia.
Article Synopsis
- The ubiquitin-proteasome system helps in managing protein levels and signaling by degrading specific proteins tagged with ubiquitin.
- A genetic study of patients with severe deafness and cataracts revealed a mutation in the PSMC3 gene that impacts protein processing, leading to abnormal protein accumulation and stress in cells.
- Zebrafish models mimicking the mutation showed similar developmental issues, indicating that the protein Rpt5 is crucial for the proper development of the inner ear, lens, and central nervous system.
Purpose: To assess the frequency of macular cysts (MCs) in retinal detachment treated with silicone oil and evaluate their impact on visual acuity and macular vascularization using optical coherence tomography-angiography.
Methods: Forty-three eyes of 41 patients treated with silicone oil for retinal detachment were retrospectively studied. Best-corrected visual acuity and 6- × 6-mm optical coherence tomography-angiography examination at least 3 months after silicone oil removal were reviewed.
Purpose: Dome-shaped macula (DSM) is characterized by an inward bulge in the macula, often associated with a myopic staphyloma. One complication of DSM is particularly studied: foveolar serous retinal detachment (SRD). This study analyzed the variations of optical coherence tomography angiography (OCT-A) decorrelation signal in cases of DSM with and without SRD.
View Article and Find Full Text PDFRobot-Assisted Simulated Strabismus Surgery.
Transl Vis Sci Technol
May 2019
Purpose: This study aims to investigate the feasibility of robot-assisted simulated strabismus surgery using the new da Vinci Xi Surgical System and to report what we believe is the first use of a surgical robot in experimental eye muscle surgery.
Methods: Robot-assisted strabismus surgeries were performed on a strabismus eye model using the robotic da Vinci Xi Surgical System. On the lateral rectus of each eye, we performed a procedure including, successively, a 4-mm plication followed by a 4-mm recession of the muscle to end with a 4-mm resection.
Purpose: The objective of this study was to determine whether the dark adaptation time was longer in highly myopic patients than in emmetropic patients and whether there was a correlation between dark adaptation results and axial length.
Patients And Methods: We conducted a retrospective study that included highly myopic patients with -6.00 dioptres or more, matched to emmetropic control patients of the same age.
Dome-shaped macula (DSM) is an entity recently described as a convex anterior protrusion of the macular area within a posterior myopic staphyloma. Specific complications were associated with DSM, like serous retinal detachment (SRD). We describe a woman presenting with a decreased vision at 20/50.
View Article and Find Full Text PDFPurpose: To determine the factors influencing the time from preterm birth and retinopathy of prematurity (ROP) detection to optimize the timing of the initial screening.
Methods: This multicenter retrospective study enrolled preterm infants born before 32 weeks of gestational age (GA) and/or weighing less than 1,500 g between January 1, 2011, and December 31, 2015. ROP screening was performed using fundus photography with a wide-field camera.
Purpose: To determine the relationship of subfoveal choroidal thickness (ChT), refraction, and axial length in children, and evaluate the evolution of subfoveal ChT with time in myopic versus nonmyopic eyes.
Methods: A total of 229 eyes of 115 children aged 2 to 16 years were included in the study. Refraction under cycloplegia, axial length, and subfoveal ChT were measured at baseline with comparative investigations at 15 months follow-up.
Introduction: Evaluation of a single injection of botulinum toxin A in infantile esotropia as an alternative choice to surgery in a retrospective cases serie.
Methods: Patients (65 consecutive children aged 9 to 26 months with infantile strabismus) underwent botulinum toxin A injection in both medial recti Botulinum toxin A injection. Clinical datas including measurement of angle of deviation before and after injection.
Background And Objective: Dome-shaped macula (DSM) has recently been described with myopic staphyloma, which may cause decreased vision. The purpose of this study was to evaluate the choroidal thickness of eyes with and eyes without DSM.
Methods: A total of 26 eyes with DSM were paired based on axial length with 26 eyes without DSM.
Intraocular cytokines imbalance in congenital cataract and its impact on posterior capsule opacification.
Graefes Arch Clin Exp Ophthalmol
May 2016
Background: Congenital cataract is of particular interest because of the variability of etiologies and the inflammatory reaction that are often observed. The aim of the study was to describe intraocular levels of various inflammation-related cytokines of patients with congenital cataract and to study their correlations with clinical determinants.
Methods: We followed a cohort of 18 patients (18 eyes) with congenital cataract from a University hospital and measured levels of various inflammation-related cytokines in the aqueous humor of patients with congenital cataract, and compared these levels to those observed in a control group (patients with senile cataract) using multiplex immunoassay.
Purpose: Dome-shaped macula (DSM) may cause impaired vision. This study analyzed the long-term evolution of DSM, most particularly macular changes: serous retinal detachment, retinal pigment epithelium atrophy, and DSM bulge increase.
Methods: Twenty-nine eyes presenting with DSM were retrospectively studied.