Ocsyn, a syntaxin-interacting protein characterized by Safieddine et al. [Safieddine, S., Ly, C.
View Article and Find Full Text PDFSpace flight produces changes in neuronal activity in the vestibular system. We studied the protein expression of the NMDA receptor subunit NR1 in the vestibular ganglia of rats exposed to microgravity for 17 days, beginning on postnatal day 8, as part of the NASA Neurolab mission. As a control, we studied the cochlear ganglia in the same way.
View Article and Find Full Text PDFWe investigated the distribution of the glutamate receptor subunits, alpha-amino-3-hydroxy-5-methyl-4 isoazolepropionic acid (AMPA) GluR2 and GluR2/R3, and N-methyl-D-aspartate (NMDA) NR1, and the timing of their appearance during early development of the mouse vestibular and spiral ganglia. NMDA NR1 was the first to be expressed, in the statoacoustic ganglion neurons on E11. GluR2/R3 immunoreactivity was detected in these neurons on E12.
View Article and Find Full Text PDFMesenchymal nonsensory regions of the inner ear are important structures surrounding the neurosensory epithelium that are believed to participate in the ionic homeostasis of the cochlea and vestibule. We report here the discovery of otospiralin, an inner ear-specific protein that is produced by fibrocytes from these regions, including the spiral ligament and spiral limbus in the cochlea and the maculae and semicircular canals in the vestibule. Otospiralin is a novel 6.
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