Publications by authors named "Claude Couquet"
Background: Flow diverting stents (FDS) have transformed the treatment of intracranial aneurysms; however, their metallic structure associated with their intra-luminal positioning hamper angiographic and clinical outcomes. Therefore, there is a need to develop FDS with optimized surfaces that reduce thrombogenicity while promoting the healing process and endothelialization.
Methods: P8RI, a peptide mimicking the CD31 protein, was previously developed and grafted onto Silk Vista (SV) FDS.
Article Synopsis
- The study compares the endothelial coverage of new coated and uncoated flow diverters (FDs) in rabbits, focusing on the effects of different antiplatelet therapies.
- Three types of FDs were implanted in rabbits, and their integration into the arterial wall was assessed after four weeks using various imaging and histopathological techniques.
- Results show that the integration of coated and uncoated FDs is similar, while the antiplatelet regimen influenced the rates of coverage, with no therapy showing the highest rate of neointimal formation.
Background: WEB Shape Modification (WSM) over time is frequent after aneurysm treatment. In this study, we explored the relationship between histopathological changes and angiographic evolution over time in experimental aneurysms in rabbits treated with the Woven EndoBridge (WEB) procedure.
Methods: Quantitative WSM was assessed using flat-panel computed tomography (FPCT) during follow-up by calculating height and width ratio (HR, WR), defined as the ratio between either measurement at an index time point and the measurement immediately after WEB implantation.
Article Synopsis
- The study examines the process of coil healing in intracranial aneurysms (IAs) using an animal model, highlighting the issues with recanalization that can affect treatment outcomes.
- 27 aneurysms in rabbits were analyzed one month post-coiling through traditional histology and advanced imaging techniques to assess healing.
- A five-stage classification of aneurysm healing was developed using nonlinear microscopy, providing a more precise evaluation tool for the effectiveness of embolization devices.*
Endovascular treatment is the first-line therapy for most intracranial aneurysms; however, recanalisation remains a major limitation. Developments in bioengineering and material science have led to a novel generation of coil technologies for aneurysm embolisation that address clinical challenges of aneurysm recurrence. This review presents an overview of modified surface coil technologies and summarises the state of the art regarding their efficacy and limitations based on experimental and clinical results.
View Article and Find Full Text PDFBackground And Purpose: In this study we tested the effect of antiangiogenics on a swine angiogenesis model that shares some brain AVM histological characteristics. The objective was to determine bevacizumab effects on retia volumes and on vessels' wall.
Materials And Methods: Fifteen pigs were divided into 3 groups: Five animals served as controls (group A), 5 animals underwent endovascular left external and common carotid artery occlusion (group B) and 5 animals underwent the same procedure and had an intra-arterial in-situ injection of bevacizumab (groupC) 2 months after the occlusion.
Uterus tolerance to extended cold ischemic storage after auto-transplantation in ewes.
Eur J Obstet Gynecol Reprod Biol
July 2017
Objective: To assess how the uterus tolerates extended cold ischemic storage before auto-transplantation in ewes.
Study Design: Fourteen uterine auto-transplantations were performed in ewes from November 2014 to June 2015 at the Analysis and Research Laboratory of Limoges, France. The animals were divided into 2 groups: 7 after 3h of cold ischemia timeand 7 after 24h.
Background: Even though flow-diverting stents are being increasingly used to treat intracranial aneurysms, the fate of jailed side branches remains controversial, with recent clinical data contradicting finding of earlier animal studies that reported patency.
Objective: To quantify the surface area of the ostia after 3 months of jailing by flow-diverting stents as a more accurate means of patency evaluation.
Methods: Ten large white swine were stented by flow-diverting stents placed at common carotid-ascending pharyngeal arterial bifurcation sites.
Background: Angiogenesis has a key role in the formation and evolution of brain arteriovenous malformations (AVMs). Numerous models have been developed aiming to recreate configuration of brain AVMs.
Objective: To develop an animal model sharing the same pathological characteristics as human brain AVMs.
Objectives: The purpose of our study was to distinguish the different components of a brain arteriovenous malformation (bAVM) on 3D rotational angiography (3D-RA) using a semi-automated segmentation algorithm.
Materials And Methods: Data from 3D-RA of 15 patients (8 males, 7 females; 14 supratentorial bAVMs, 1 infratentorial) were used to test the algorithm. Segmentation was performed in two steps: (1) nidus segmentation from propagation (vertical then horizontal) of tagging on the reference slice (i.
Aim: Our goal was to demonstrate the feasibility of pelvic magnetic resonance imaging (MRI) in the ewe.
Material And Methods: Two ewes underwent a pelvic 3 Tesla MRI scan, under light anesthesia, with T2-weighted fast spin-echo images and T1-weighted spoiled gradient-echo images. Multiplan T1 weighted images were also obtained after the intravenous injection of a contrast product.
Experimentally infected sheep have been previously developed as an animal model of trypanosomosis. We used this model to test the efficacy of megazol on eleven Trypanosoma brucei brucei-infected sheep. When parasites were found in blood on day 11 post-infection, megazol was orally administered at a single dose of 40 or 80mg/kg.
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