Performance of the AmpliSeq NGS Panel in Thyroid Nodules with Indeterminate Cytology.

Objective: Fine needle aspiration (FNA) cytological analysis fails to confirm the benignity or malignancy of Bethesda III, IV and V thyroid nodules. Molecular tests performed on FNA samples have demonstrated interesting results in improving the diagnosis of these nodules. The aim of this study was to assess the performance of a large next-generation sequencing (NGS) panel in thyroid nodules with indeterminate cytology (Bethesda III, IV, V).

Next-Generation-Sequencing on fine needle aspirates in neck recurrence of thyroid cancers.

Objectives: Tumor molecular genotyping plays a key role in improving the management of advanced thyroid cancers. Molecular tests are classically performed on Formalin-Fixed Paraffin-Embedded (FFPE) carcinoma tissue. However alternative molecular testing strategies are needed when FFPE tumoral tissue is unavailable.

[Salivary gland cytopathology: Milan system 2018].

The salivary glands cytology is one of the most challenging area in cytopathology because of the wide diversity of benign and malignant tumors also because of their heterogeneity. However, fine needle aspiration cytology, with magnetic resonance imaging, represents a first-line examination to guide a possible surgical procedure and its extent. An accurate diagnosis of a specific tumor is sometimes difficult to assess in cytology.

A multicentre validation study for the EU-TIRADS using histological diagnosis as a gold standard.

Objective: Many systems for risk stratification of thyroid nodule with ultrasound (US) have been proposed and the EU-TIRADS issued by the ETA in 2017 was the last to have been published. The present study was undertaken to evaluate whether the malignancy risk of each category corresponded to the given range of the guidelines and assess the diagnostic value of EU-TIRADS in a multi-institutional trial with histology as gold standard.

Design: Three institutions in Switzerland, France and United Kingdom shared this retrospective study.

What is the care pathway of patients who undergo thyroid surgery in France and its potential pitfalls? A national cohort.

Context: The rate of thyroid cancer is increasing in France, as well as concerns about overdiagnosis and treatment.

Objectives: To examine the care pathway of patients who undergo thyroid surgery in France and detect potential pitfalls.

Design: A large observational study based on medical reimbursements, 2009-2011.

Prospective evaluation of thyroid imaging reporting and data system on 4550 nodules with and without elastography.

Objective: To evaluate prospectively the diagnostic accuracy of the thyroid imaging reporting and data system (TI-RADS) and its interobserver agreement and to estimate the reduction of indications of fine-needle aspiration biopsies (FNABs).

Design: A prospective comparative study was designed.

Methods: In 2 years, 4550 nodules in 3543 patients were prospectively scored using a flowchart and a six-point scale and then submitted to US-FNAB.

T-cell receptor Vbeta repertoire in nodal non-anaplastic peripheral T-cell lymphomas.

The aim of this study was to evaluate the T-cell receptor (TCR) Vbeta repertoire in the two main histological subtypes of nodal non-anaplastic peripheral T-cell lymphoma: Not Otherwise Specified (NOS) and angioimmunoblastic lymphoma (AIL). Frozen lymph node tissues of eight NOS and six AIL were analyzed. A reverse transcriptase polymerase chain reaction (RT-PCR) was carried out to assess the expression of the 24 Vbeta gene families.