Publications by authors named "Claude Bachmeyer"
Objectives: To investigate factors associated with dermatomyositis (DM) complete clinical response and overall survival with a focus on the use of immunosuppressive therapies in patients with cancer-associated DM.
Methods: We performed a multicentre, retrospective cohort study. Multivariable survival analyses used a Cox model with time-dependent covariates and adjustments with inverse probability censoring weighting.
Objectives: To evaluate the ability of FDG PET/CT, at diagnosis of giant cell arteritis (GCA) and during follow-up, to predict occurrence of relapse in large-vessel GCA (LV-GCA).
Methods: We conducted a retrospective study using the French Study Group for Large-Vessel Vasculitis (GEFA) network. Data from patients with LV-GCA diagnosed by PET/CT and who had PET/CT in the following year were collected.
Intestinal Candida albicans overgrowth in IgA deficiency.
J Allergy Clin Immunol
September 2023
Background: Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether human IgA-deficiency is associated with gut fungal dysbiosis remains unknown.
Objectives: Our goal was to study the impact of IgA on gut mycobiota ecology.
Trichophyton indotineae is a newly described dermatophyte species. This fungal pathogen has recently emerged in India and is responsible for chronic or recurrent widespread superficial infections. Resistance to terbinafine is frequently associated to this pathogen and is related to point mutations in the gene encoding the squalene epoxidase.
View Article and Find Full Text PDFObjective: The frequency of vasculitis may be increased in patients with Familial Mediterranean Fever (FMF), according to several studies. Our aim was to assess the characteristics of French adult patients with both diseases.
Methods: Patients with vasculitis were selected from patients followed for FMF in the French JIR-cohort.
Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was diagnosed in France. Analysis of internal transcribed spacer sequences revealed the wide spread of this species in Asia and Europe. Detection of T.
View Article and Find Full Text PDFIgG4-Related Disease (IgG4-RD) results from tissue infiltration by IgG4-expressing plasma cells and lymphocytes, leading to fibrosis and organomegaly. Clinical presentation is remarkably variable according to organ involvement, and high IgG4 serum concentration, initially considered a diagnostic hallmark of IgG4-RD, tends to be forgone as an indispensable criterion for its diagnosis; it can indeed be absent in some patients, highlighting the diversity of presentation of this dysimmune condition. Nevertheless, elevation of IgG4 serum concentration in suggestive settings remains an argument in favour of IgG4-RD, and while other IgG subclasses can be elevated, this biological feature lacks any diagnostic value.
View Article and Find Full Text PDFArticle Synopsis
- GCA (Giant Cell Arteritis) is a type of vasculitis where the triggers are unknown, and the study aims to explore the effects of JAK2p.V617F-mutated myeloproliferative neoplasms (MPNs) on GCA patients while also screening for clonal hematopoiesis (CH) in those without MPNs.
- In a retrospective study, 21 GCA patients with MPNs were compared to 42 GCA patients without MPNs, revealing that those with MPNs had fewer cephalic symptoms and higher platelet counts, while their overall survival was significantly shorter.
- The study detected CH mutations in 33% of GCA patients
Purpose: To describe characteristics and outcomes of patients with giant cell arteritis (GCA)-related aortic dissection.
Patients And Methods: We retrospectively included, through a nationwide GCA network, all patients who had an aortic dissection either revealing GCA or occurring during follow-up.
Results: A total of 46 patients were included in this study.
Article Synopsis
- * It analyzed clinical data from 29 KTR patients with severe onychomycosis, finding that over half had concerns about prescribing oral treatments due to altered renal parameters and lack of guidelines.
- * Results showed that oral terbinafine was well-tolerated in KTR patients on different antirejection therapies, with only mild adverse events reported, suggesting its potential as a safe treatment option and the need for further research to create treatment guidelines.
Background: Interest for the study of gut mycobiota in relation with human health and immune homeostasis has increased in the last years. From this perspective, new tools to study the immune/fungal interface are warranted. Systemic humoral immune responses could reflect the dynamic relationships between gut mycobiota and immunity.
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