Publications by authors named "Clarke Lorelei"

A 4-year-old Nigerian Dwarf wether presented for chronic regurgitation and cervical swelling of three years duration. Physical examination revealed a large ventral cervical mass. The goat made repeated attempts to swallow and regurgitate, but the mass did not change significantly in size.

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Klebsiella spp. are gram-negative facultative anaerobic heavily encapsulated bacteria associated with opportunistic and primary infections in a wide range of species. We assessed a series of cases (n=8) of necrosuppurative peritonitis, lymphadenitis, and/or pyelonephritis in wild juvenile raccoons (Procyon lotor) that died under rehabilitator care in New York, New Jersey, and Wisconsin, US, between July 2020 and December 2023, plus a retrospective case of a juvenile raccoon necropsied from New York in August 2011.

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Article Synopsis
  • Intravenous regional limb perfusion (IVRLP) is an effective method for treating infections in birds, allowing high local drug concentrations while reducing side effects.
  • The study focused on amikacin dosing in healthy leghorn hens, administering a single 10 mg/kg dose of amikacin via IVRLP and measuring its tissue absorption.
  • Results showed peak tissue concentrations one hour after administration, suggesting that repeating the procedure every 24 hours is advisable for effective treatment, though the duration may vary based on individual cases.
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Aspergillosis is a major cause of morbidity and mortality in penguins, with triazole antifungal drugs being commonly used for prophylaxis and treatment. This report describes 15 cases of fatal hemolysis associated with liquid itraconazole and voriconazole formulations administered to African penguins () from four institutions. All penguins underwent stressful events (e.

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A free-ranging Eastern gray squirrel (Sciurus carolinensis) was presented for ulcerated cutaneous masses at the base of both pinnae in July 2021. Diagnosis of cutaneous histiocytosis was achieved by histologic and immunohistochemical examination of one excised mass and supported by spontaneous resolution of the contralateral mass before the squirrel's release.

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Article Synopsis
  • Since 2010, Wisconsin has seen an increase in commercial white-tailed deer farming, raising concerns about new disease patterns due to high deer populations.
  • An analysis of 277 postmortem cases from the Wisconsin Veterinary Diagnostic Laboratory revealed that 81.9% of cases had identifiable diagnoses, with fawns being notably more likely to have health issues.
  • The most prevalent diseases found included bronchopneumonia and enteritis/enterocolitis, with common pathogens identified being specific viruses and nutritional deficiencies also noted as significant non-infectious health problems.
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There have been unpublished reports of a follicular dysplastic syndrome in adult white-tailed deer (; WTD), known colloquially as "toothpaste hair disease." The current report aims to describe the gross and histologic lesions in skin samples from 2 adult WTDs that presented to the Wisconsin Department of Natural Resources and the Wisconsin Veterinary Diagnostic Laboratory with reports of hair loss in 2018. Both cases were grossly alopecic with sparing of the distal extremities and variably the head and neck.

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Here we characterize 6 cases (4 autopsies and 2 biopsies) of histiocytic sarcoma in the CNS of cats. All affected cats had chronic, progressive clinical signs. Three autopsied cats were euthanized because of a poor prognosis, and one died.

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Regional limb perfusion (RLP) has been used to treat cases of distal limb infections in avian species. Potentially nephrotoxic drugs, such as amikacin, may increase the risk of nephrotoxicity with RLP because of the presence of the renal portal system and direct venous blood flow from the pelvic limbs to the kidneys. In a randomized, blinded, placebo-controlled study, the safety of repeated amikacin administration (20 mg/kg q24h for 3 doses) via RLP was evaluated in healthy female chickens (; n = 8 treatment, n = 8 saline control group).

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Arboviral disease is of increasing concern to human and animal health professionals as emerging and re-emerging arboviruses are more frequently recognized. Wildlife species are known to play a role in the transmission and maintenance of arboviruses and infections can result in morbidity and mortality in wildlife hosts. In this review, we detail existing evidence of white-tailed deer () as an important host to a diverse collection of arboviruses and evaluate the utility of this species as a resource to better understand the epidemiology of related viral diseases.

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South American camelids (SACs) have become increasingly popular as livestock and companion animals in the Midwestern United States. With increased ownership, postmortem evaluations and samples available for diagnostic assessment are being submitted more frequently to veterinary diagnostic laboratories. We searched archived pathology records at the Wisconsin Veterinary Diagnostic Laboratory (WVDL) between 2009-2019 for SAC cases.

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Rift Valley fever phlebovirus (RVFV) is a mosquito-transmitted phlebovirus (Family: Phenuiviridae, Order: Bunyavirales) causing severe neonatal mortality and abortion primarily in domestic ruminants. The susceptibility of young domestic swine to RVFV and this species' role in geographic expansion and establishment of viral endemicity is unclear. Six commercially bred Landrace-cross piglets were inoculated subcutaneously with 105 plaque-forming units of RVFV ZH501 strain and two piglets received a sham inoculum.

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A 7-year-old male neutered Labrador Retriever dog presented with acute-onset fever, shifting limb lameness and anorexia, with development of acute respiratory distress. At necropsy, there was vegetative endocarditis, which effaced the aortic valve. Gram staining of impression smears from the aortic valve and kidney revealed numerous gram-positive rods with some coryneform bacteria.

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We investigated whether naturally acquired maternal antibodies to epizootic hemorrhagic disease virus serotype 2 (EHDV-2) would protect white-tailed deer (Odocoileus virginianus) fawns against infection and clinical disease following an EHDV-2 challenge. We compared viremia and clinical response in 27-47-d-old, experimentally infected fawns with and without maternally derived antibodies to EHDV-2. Mild to moderate clinical signs were observed in four seronegative (maternal antibody-negative) fawns, which were viremic from 3 to 14 d postinoculation.

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Case Description: A client-owned 12-year-old 10.3-kg (22.7-lb) female shusui koi () was evaluated because of an ulcerated mass on the left body wall, hyporexia, and decreased activity.

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Article Synopsis
  • The study explores using natural language data from veterinary necropsy reports to monitor animal populations for signs of disease outbreaks and bioterrorism threats.
  • Machine learning methods were evaluated for their effectiveness in identifying gastrointestinal, respiratory, and urinary issues in these reports, particularly using a random forest model with TF-IDF statistics.
  • The successful model processed over 33,000 reports, revealing disease trends over 14 years and highlighting a significant case of gastrointestinal disease linked to a specific producer in 2016.
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In a review of 159 archived bovine autopsy cases submitted to the Georgia Veterinary Diagnostic Laboratory System from 2001 to 2017, we evaluated histologic lesions and other laboratory test results in cases diagnosed with central nervous system (CNS) disease to determine the most common disorders and the rate of definitive morphologic and etiologic diagnosis within the population. The most common breed was Aberdeen Angus or Angus (31%), and female animals comprised 60% of the overall submissions. Gross anatomic changes were described in 33% of cases that had histologic lesions.

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Bluetongue virus serotype 3 (BTV-3) has been found in the US since 1999 and was recently identified in white-tailed deer (WTD; ) found dead in Virginia, US and West Virginia, US in 2016. Bluetongue viruses are known to cause pathologic changes in WTD; however, the relative virulence and pathogenicity of BTV-3 in WTD is unknown. In our study, eight WTD fawns, 6-12 wk old, were needle inoculated subcutaneously with a field isolate of BTV-3, with one fawn shaminoculated as a control during July 2017; all were monitored to determine the pathogenicity of BTV-3 in WTD.

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Heartland virus (HRTV) is a North American suspected to be transmitted by the lone star tick . White-tailed deer (WTD) have been shown to develop HRTV-neutralizing antibodies following experimental infection. To further define the geographic distribution of HRTV through retrospective sampling of WTD, sera from the WTD herd health serum archive at the Southeastern Cooperative Wildlife Disease Study between 2001 and 2015 were analyzed using serum neutralization.

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