Patients with antiphospholipid antibodies preferentially seek health information from physicians: a cross-sectional online patient quantitative survey.

Little is known about how patients with antiphospholipid syndrome (APS) or antiphospholipid antibodies (aPL) access and trust health information. This research aimed to: describe the sources of information most frequently accessed/trusted by patients with APS/aPL; identify if individuals with APS/aPL perceived their health had been negatively impacted by various sources and document obstacles to accessing health information. Patients meeting Revised Sapporo Criteria for APS or with ≥1 positive aPL on ≥2 occasions were recruited to an online survey regarding their health information use at diagnosis and within 6 months preceding survey completion.

Understanding Resistance Among Survivors of Domestic Violence and Abuse: A Co-Produced Study in the United Kingdom.

Domestic violence and abuse (DVA) is a global problem that affects approximately one in four women in their lifetime. An area of unexplored research is how women use a range of strategies to honor resistance, manage the risk, avoid abuse, and cope with the pain of DVA. Art-based methodology and interpretative phenomenological analysis approaches were used which determined seven strategies employed by women in order to survive DVA: apparent compliance; maintaining a sense of self; knowing boundaries; keeping hope in sight; imagining freedom; degrees of rebellion; and denial.

COVID-19 outbreaks in nursing homes in Los Angeles County, March 2020-April 2022.

Introduction: Nursing home (NH) residents have an elevated risk of coronavirus disease 2019 (COVID-19) infection and severe outcomes. However, literature regarding outbreak outcomes at the facility level is limited.

Methods: NH outbreaks beginning between March 1, 2020, and February 22, 2022, at facilities under Los Angeles County jurisdiction were assigned to 1 of 6 time periods defined by dominant variants, surges in community transmission, and vaccination levels.

Understanding early maladaptive schemas in autistic and ADHD individuals: exploring the impact, changing the narrative, and schema therapy considerations.

Autistic/ADHD individuals are increasingly recognised as a valid minority group, with consistent research demonstrating a higher prevalence of co-occurring mental health conditions such as PTSD, anxiety, depression, substance use, and eating disorders among other mental health challenges. Due to this, there is increasing focus on the adaptations required for Autistic and ADHD individuals of current therapeutic approaches such as Schema Therapy. Particular emphasis when creating these adaptations needs to include looking at the developmental experiences, social influences, and continued adversity faced by Autistic and ADHD individuals across the lifespan, and how the narrative around Autism and ADHD within psychotherapy in general needs to change.

Prevalence of dementia among Indigenous populations of countries with a very high Human Development Index: a systematic review.

Dementia is a health priority for Indigenous peoples. Here, we reviewed studies on the prevalence of dementia or cognitive impairment among Indigenous populations from countries with a very high Human Development Index (≥0·8). Quality was assessed using the Joanna Briggs Institute risk-of-bias tool and CONSolIDated critERia for strengthening the reporting of health research involving Indigenous peoples (CONSIDER), with oversight provided by an Indigenous Advisory Board.

Review of a specialist Rett syndrome clinic from 2003 to the COVID pandemic: clinic experience and carer perspectives.

Background: We have held a 'trouble-shooting' clinic for Rett syndrome patients from 2003 until the COVID pandemic in 2020. The clinic was multidisciplinary, including clinical genetics, paediatric neurology, adult learning disability psychiatry and physiotherapy. Access to specialist communication support and eye-gaze equipment was also often available.

Providing 'professionalism with compassion'; how the time for caring communication can improve experiences at the end-of-life at home, findings from a realist evaluation.

Background: For many patients and caregivers, attending to dying and death at home will be a new and fearful experience. This research brings new evidence on the central support of the Rapid Response Service (RRS), provided to those who chose to die at home. RRS's are variable, although all seek to avoid unwanted hospital admissions and to respond flexibly to suit individual preferences for support.

Supporting individuals with a visible difference: A UK survey of needs and preferences.

Individuals with visible differences, resulting from injuries, health conditions, or treatment, can face varied and lasting psychosocial effects. Existing psychosocial interventions are limited, with inconsistent support noted by specialists. Improved provision and accessibility are crucial; yet, the self-perceived needs remain underreported.

Corrigendum to "Genetic Variants of Are Major Determinants of Kidney Failure in People of African Ancestry With HIV" [ Volume 7, Issue 4, April 2022, Pages 786-796].

[This corrects the article DOI: 10.1016/j.ekir.

Evaluating the home-based intervention strategy (HIS-UK) to reduce new chlamydia infection among young men aged 16-25 years by promoting correct and consistent condom use: findings from a randomised controlled trial.

Background: Correct and consistent condom use is the most effective method to reduce transmission of sexually transmitted infections (STIs).

Objective: To compare the HIS-UK intervention to usual condom information and distribution care for effect on chlamydia test positivity.

Methods: Trial design A 3-parallel arm randomised controlled trial (1:1:1 allocation, two intervention arms vs.

Unraveling the effects of the Ebola experience on behavior choices during COVID-19 in Liberia: a mixed-methods study across successive outbreaks.

Background: The burden of the COVID-19 pandemic in terms of morbidity and mortality differentially affected populations. Between and within populations, behavior change was likewise heterogeneous. Factors influencing precautionary behavior adoption during COVID-19 have been associated with multidimensional aspects of risk perception; however, the influence of lived experiences during other recent outbreaks on behavior change during COVID-19 has been less studied.

MirGeneDB 3.0: improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families and updated covariance models.

We present a major update of MirGeneDB (3.0), the manually curated animal microRNA gene database. Beyond moving to a new server and the creation of a computational mirror, we have expanded the database with the addition of 33 invertebrate species, including representatives of 5 previously unsampled phyla, and 6 mammal species.

Non-criteria antiphospholipid antibody profiles and thrombotic outcomes in a cohort of patients with systemic lupus erythematosus.

Objectives: Antiphospholipid syndrome (APS) is characterised by the presence of antiphospholipid antibodies (aPLs) and clinical outcomes of thrombosis and/or obstetric morbidity and is associated with systemic lupus erythematosus (SLE). IgG antiphosphatidylserine/prothrombin complex (aPS/PT), IgM aPS/PT and IgG anti-beta 2 glycoprotein 1-domain 1 (aβ2GP1-D1) are novel aPLs that have been associated with thrombosis; however, conclusive data are still lacking. It remains unclear how best to incorporate non-criteria autoantibodies into clinical decision-making.

Asparagine availability controls germinal center B cell homeostasis.

The rapid proliferation of germinal center (GC) B cells requires metabolic reprogramming to meet energy demands, yet these metabolic processes are poorly understood. By integrating metabolomic and transcriptomic profiling of GC B cells, we identified that asparagine (Asn) metabolism was highly up-regulated and essential for B cell function. Asparagine synthetase (ASNS) was up-regulated after B cell activation through the integrated stress response sensor GCN2.

The effect of target scarcity on visual foraging.

Previous studies have investigated the effect of target prevalence in combination with the effect of explicit target value on human visual foraging strategies, though the conclusions have been mixed. Some find that individuals have a bias towards high-value targets even when these targets are scarcer, while other studies find that this bias disappears when those targets are scarcer. In this study, we tested for a bias for scarce targets using standard feature versus conjunction visual foraging tasks, without an explicit value being given.

Mindfulness meditation is associated with global EEG spectral changes in theta, alpha, and beta amplitudes.

Mindfulness meditation is linked to a broad range of psychological and physical health benefits, potentially mediated by changes in neural oscillations. This study explored changes in neural oscillations associated with both immediate and regular mindfulness meditation practice. Electroencephalographic (EEG) data were collected from 40 healthy young adults (M = 20.

Development and validation of a clinical prediction tool to estimate survival in community-dwelling adults living with dementia: a protocol.

Introduction: A clinical prediction tool to estimate life expectancy in community-dwelling individuals living with dementia could inform healthcare decision-making and prompt future planning. An existing Ontario-based tool for community-dwelling elderly individuals does not perform well in people living with dementia specifically. This study seeks to develop and validate a clinical prediction tool to estimate survival in community-dwelling individuals living with dementia receiving home care in Ontario, Canada.

Symptomatology and Management of Adult Anaphylaxis according to Trigger: A Cross-Sectional Study.

Introduction: Anaphylaxis is an acute life-threatening allergy, most commonly provoked by food, venom, or drugs. There is limited data regarding differences in symptomatology between anaphylaxis provoked by different triggers. This study aimed to assess sociodemographic characteristics, clinical symptoms, and management of anaphylaxis, according to triggers in adults.

Variation Exists in Service Delivery: Similarities and Differences in the Provision of a Whole Genome Sequencing Service for Paediatric Rare Disease Patients in the National Health Service in England.

Introduction: The National Health Service (NHS) in England is the first to offer whole genome sequencing (WGS) as part of standard care. As a high-income country with a universal healthcare system, England contributes a valuable perspective to global developments in WGS.

Methods: We used an implementation science approach with mixed methods to characterise delivery of WGS for paediatric rare diseases: observations and field notes of consent appointments in clinical genetics and mainstream settings and follow-up qualitative semi-structured interviews with the clinical team.

Pandemic-related resilience in HPV vaccination programmes - Perspectives from selected countries in Africa on what it will take to vaccinate 90 % of girls by 2030.

The COVID-19 pandemic resulted in widespread disruptions to primary health care and other sectors, halting the majority of routine immunisation services and particularly impacting newer, less routinized HPV vaccine programmes. We present a series of five country case studies, drawing directly from frontline experiences in Côte d'Ivoire, Kenya, Liberia, Zambia, and Senegal to explore potential barriers and enablers of national HPV vaccine programme resiliency in the aftermath of a pandemic. A series of common themes emerged, articulating common challenges to maintaining HPV vaccine programmes, common factors that supported programme resilience, and common themes of resource needs to rebuild stronger routine immunisation programmes to face future threats.