Publications by authors named "Clarice G Zhou"
Article Synopsis
- The study examines how the time of day affects the likelihood of operative vaginal births (OVBs) compared to spontaneous vaginal births (SVBs) using U.S. birth data from 2016 to 2021.
- After analyzing over 15 million births, it was found that OVBs were more common during the late afternoon (4:30-7:30 p.m.) and less common in the early morning (3:00-6:00 a.m.).
- The results suggest that different times of day influence the use of birth intervention methods, indicating a need for further research into the reasons behind these temporal trends.
Objective: Antenatal corticosteroids given prior to preterm deliveries reduce the risk of adverse neonatal outcomes. However, steroid administration in the setting of a viral respiratory infection can worsen maternal outcomes. Therefore, the decision to administer corticosteroids must balance the neonatal benefits with the potential harm to the mother if she is infected with the novel coronavirus disease 2019 (COVID-19).
View Article and Find Full Text PDFSpectral-domain optical coherence tomography (SD-OCT) is an accessible clinical tool for measuring structural changes to the retina, and increasingly as a biomarker for brain-predominant neurodegenerative diseases like Alzheimer's. Information about retinal function can also be extracted from OCT images, but is under-studied, with literature examples often employing challenging protocols or requiring specialized hardware. The first goal of this study was to verify that functional retinal imaging was feasible with a commercially-available SD-OCT device and a clinically practical protocol.
View Article and Find Full Text PDFBackground: While antenatal corticosteroids are routinely used to decrease adverse neonatal outcomes following preterm delivery, corticosteroids are also associated with worse outcomes in patients with viral respiratory infections. Currently in the setting of the COVID-19 pandemic, it is unclear whether antenatal corticosteroids for infant benefit outweigh the potential harm to a pregnant woman with a COVID-19 infection.
Objective: To determine at which gestational ages administering antenatal corticosteroids is the optimal management strategy for hospitalized women with preterm prelabor rupture of membranes (PPROM) who have a COVID-19 infection.
Objective: To evaluate the cost effectiveness of three different approaches to the care of neonates born at 22 weeks of gestation: universal resuscitation, selective resuscitation, or no resuscitation.
Methods: We constructed a decision-analytic model using TreeAge to compare the outcomes of death and survival with and without neurodevelopmental impairment in a theoretical cohort of 5,176 neonates (an estimate of the annual number of deliveries that occur in the 22nd week of gestation in the United States). We took a societal perspective using a lifetime horizon, and all costs were expressed in 2017 U.
Article Synopsis
- Fragile X syndrome is the leading known genetic cause of autism and is linked to the loss of the FMR1 protein, which is crucial for RNA binding.
- Research indicates that individuals with Fragile X syndrome have immune system defects, showing increased susceptibility to infections and reduced ability to clear bacteria by immune cells.
- The study reveals that FMR1 is important for the functioning of immune cells in both body and brain, impacting processes like neuronal clearance after injury and brain development essential for learning and memory.
Most metazoans undergo dynamic, circadian-regulated changes in behavior and physiology. Currently, it is unknown how circadian-regulated behavior impacts immunity against infection. Two broad categories of defense against bacterial infection are resistance, control of microbial growth, and tolerance, control of the pathogenic effects of infection.
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