Publications by authors named "Claresa S Levetan"
Objective: To elucidate why diabetes is so difficult to treat despite the present tools and pharmacologic armamentarium and to provide insights into emerging therapies by describing human and rodent data that demonstrates the ability to transform progenitor cells within the adult pancreas into new islets.
Methods: A literature review focused on the distinctions between human and rodent islets.
Results: We are beginning to elucidate important differences between the architecture and composition of the islets of Langerhans in humans and rodents.
Objective: To identify triggers for islet neogenesis in humans that may lead to new treatments that address the underlying mechanism of disease for patients with type 1 or type 2 diabetes.
Methods: In an effort to identify bioactive human peptide sequences that might trigger islet neogenesis, we evaluated amino acid sequences within a variety of mammalian pancreas-specific REG genes. We evaluated GenBank, the Basic Local Alignment Search Tool algorithm, and all available proteomic databases and developed large-scale protein-to-protein interaction maps.
Objectives: The National Cholesterol Education Program (NCEP) has enhanced public awareness of the importance of cholesterol in the development of heart disease, yet most patients with cardiovascular disease (CVD) do not know or achieve their low-density lipoprotein cholesterol (LDL-C) goals. This randomized, controlled trial was designed to evaluate the impact of a system that provides uniquely formatted laboratory results to patients with CVD on their changes in LDL-C levels.
Methods: Eighty patients with CVD were randomized to receive standard care or the intervention inclusive of a computer-generated, 11''x17'' color poster depicting an individual's LDL-C status and goals along with personalized steps to aid in goal achievement.
Purpose: To discuss studies that investigate the understanding of patients with diabetes and the information provided by physicians regarding the terminology and meaning of tests for glycated hemoglobin.
Findings: Patients with diabetes seldom know or remember the terminology for glycated hemoglobin assay techniques, even when they are participating in self-monitoring of blood glucose. Physicians use a variety of terms for the glycated hemoglobin test and are not consistent in their terminology.
Objective: To review published data about the relationship between hyperglycemia and the outcome of patients with stroke.
Results: Stroke is the most frequent cause of permanent disability in the Western world and the third leading cause of death among Americans. Each year, more than 500,000 Americans have a cerebrovascular accident.
Objective: The public is increasingly aware of the importance of HbA(1c) testing, yet the vast majority of patients with diabetes do not know their HbA(1c) status or goal. We set forth to evaluate the impact of a system that provides uniquely formatted and personalized reports of diabetes status and goals on changes in HbA(1c) levels.
Research Design And Methods: A total of 150 patients with diabetes were randomized to receive either standard care or intervention inclusive of a computer-generated 11" x 17" color poster depicting an individual's HbA(1c) status and goals along with personalized steps to aid in goal achievement.