Clinical pharmacology and pharmacokinetics of clonidine.

A 300-mug oral dose of clonidine was administered to 5 normal volunteers and measurements of plasma concentration and effects upon blood pressure, heart rate, circulatory reflexes, sedation, and dry mouth were made for the following 8 hr. The plasma concentration rose to a peak of 1.02 +/- 0.

Alveolar gas concentrations of fluorocarbons-11 and-12 in man after use of pressurized aerosols.

, , 95-98. In dogs, inhalation of fluorocarbon aerosol propellants sensitizes the heart to arrhythmias provoked by intravenous injection of adrenaline. In this research, the concentrations of fluorocarbons-11 and -12, CClF and CClF, have been measured in alveolar gas in man after using pressurized aerosol inhalers.