Publications by authors named "Clare Mundell"
Article Synopsis
- Phase three trials of the monoclonal antibodies lecanemab and donanemab have shown promising results in treating early Alzheimer’s disease, with some countries already using these drugs while the UK is considering them for regulatory approval.
- A study estimated that around 906 individuals per year in two National Health Service trusts qualify for these treatments based on clinical trial criteria, suggesting a national demand of about 30,200 patients.
- The findings indicate that implementing these monoclonal antibody treatments could strain healthcare resources, highlighting the need for careful planning to meet the potential demand for such therapies in the UK.
An observational study of clozapine induced sedation and its pharmacological management.
Eur Neuropsychopharmacol
January 2016
Clozapine induced sedation is common but its management is unclear. We analyzed the factors associated with clozapine-induced sedation and the efficacy of common pharmacological strategies. We conducted a naturalistic observational study using two years electronic records of a cohort patients and three analyses: a cross sectional analysis of factors associated with total number of hours slept (as an objective proxy of sedation), and two prospective analyses of which factors were associated with changes in hours slept and the efficacy of two pharmacological strategies.
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