Early diagnosis and effective management of sepsis.

Sepsis is a complex condition defined as one or more life-threatening organ dysfunctions caused by a dysregulated host response to infection. Nurses have a vital role in the early identification of those with or at risk of developing sepsis. Prompt early treatment delivered using care bundles such as the 'sepsis six' can optimise patients' chances of survival and reduce the debilitating effects of this condition.

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.

Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.

Design, Setting, And Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin.