Publications by authors named "Clara-L Sandmann"
Article Synopsis
- This study examines the evolutionary roots of over 7,000 newly identified short open reading frames (sORFs) in humans, finding that many are relatively new in evolutionary terms and formed de novo.
- Researchers discovered 221 previously overlooked sORFs that can generate tiny peptides, smaller than any known human microprotein.
- Through mass spectrometry and cellular assays, the study links these small peptides to important biological processes like mRNA splicing and translational regulation, shedding light on the role of young proteins in the human proteome.
