Publications by authors named "Clara-Eva Paquereau"
Article Synopsis
- Apicomplexan parasites like Toxoplasma and Plasmodium invade host cells via the secretion of crucial organelles, specifically micronemes and rhoptries.
- The protein CLAMP is vital for the invasion process in Toxoplasma and Plasmodium, but its role in Plasmodium sporozoites, which are the mosquito stage of malaria, was previously unclear.
- Using a novel genome editing technique, researchers deleted the clamp gene in Plasmodium berghei and found that while sporozoite development wasn't affected, their ability to invade mosquito salivary glands and mammalian liver cells was significantly impaired, highlighting the importance of CLAMP in the parasite's life cycle.
Industrial production of therapeutic monoclonal antibodies is mostly performed in eukaryotic-based systems, allowing posttranslational modifications mandatory for their functional activity. The resulting elevated product cost limits therapy access to some patients. To address this limitation, we conceptualized a novel immunotherapeutic approach to redirect a preexisting polyclonal antibody response against Epstein-Barr virus (EBV) toward defined target cells.
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