Publications by authors named "Clara Yukhtman"
Background: Patients with severe hemophilia A and inhibitors are at risk of bleeding during invasive procedures. The standard of care for preventing perioperative bleeding has been replacement therapy with FVIII concentrates or for patients with high-titer inhibitors, bypassing agents. However, there is no consensus on the appropriate management of surgery in patients receiving the novel agent emicizumab.
View Article and Find Full Text PDFBackground: 3' RNA sequencing provides an alternative to whole transcript analysis. However, we do not know a priori the relative advantage of each method. Thus, a comprehensive comparison between the whole transcript and the 3' method is needed to determine their relative merits.
View Article and Find Full Text PDFArticle Synopsis
- A traditional method of studying complex diseases focuses on finding genes with overall expression differences between healthy and diseased individuals, but this can overlook individual gene contributions due to population diversity.
- By analyzing gene expression changes in over 100 genetically distinct mouse strains, researchers identified genes linked to heart disease severity that may be missed in broader analyses.
- These identified genes are not only relevant to cardiac diseases in mice but also interact significantly with human cardiac disease genes, highlighting the need for personalized approaches to discover and treat complex diseases effectively.