The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer is that a large part of the tumor volume is composed of a stroma with different cells and factors. Among these, we can highlight the cytokines, which perform their function through binding to their receptors.

Prevalence and severity-based classification of sensory processing issues. An exploratory study with neuropsychological implications.

Sensory processing issues, mainly known as sensory processing disorder or SPD, are frequent in children with neurodevelopmental disorders and are associated with learning and behavioral difficulties. However, previous studies suggest that these disturbances might also be present in typically developing children, reaching prevalence rates of 10-20%. Nevertheless, published studies have been primary been conducted in non-European countries.

Characterization of Permeability Barrier Dysfunction in a Murine Model of Cutaneous Field Cancerization Following Chronic UV-B Irradiation: Implications for the Pathogenesis of Skin Cancer.

Chronic ultraviolet B (UV-B) irradiation is known to be one of the most important hazards acting on the skin and poses a risk of developing photoaging, skin with cutaneous field cancerization (CFC), actinic keratosis (AKs), and squamous cell carcinomas (SCCs). Most of the UV-B light is absorbed in the epidermis, affecting the outermost cell layers, the stratum corneum, and the stratum granulosum, which protects against this radiation and tries to maintain the permeability barrier. In the present work, we show an impairment in the transepidermal water loss, stratum corneum hydration, and surface pH after chronic UV-B light exposure in an immunologically intact mouse model (SKH1 aged mice) of skin with CFC.