Publications by authors named "Clara Odilia Inocente"
Objective: A defect of the waking systems could constitute a factor of vulnerability for sudden infant death syndrome (SIDS). A decrease in orexin levels, which promotes wakefulness and activates histaminergic neurons (another hypothalamic wake-promoting system) has already been demonstrated between 2 and 6 months. This work aims to study the levels of histamine (HA), tele-methylhistamine (t-MeHA), its direct metabolite, and t-MeHA/HA ratio in the cerebrospinal fluid (CSF) of healthy children, to evaluate the maturation of the histaminergic system and its possible involvement in SIDS.
View Article and Find Full Text PDFObjectives: To characterize the rapid weight gain (RWG) phenotype associated with the onset of childhood narcolepsy and to determine whether it could constitute a marker of severity of the disease.
Methods: RWG was defined using the BMI z-score slope reported to one year (>0.67 SD) from symptom onset to disease diagnosis.
Article Synopsis
- The study compared symptoms and sleep characteristics in patients with narcolepsy-cataplexy diagnosed before and after age 18, using questionnaires and sleep studies on 46 children and 46 adults.
- Results showed that children exhibited more obesity, night eating, parasomnia, sleep talking, and sleep drunkenness, while adults experienced more sleep paralysis and lower overall quality of life.
- Despite these differences, both groups reported similar levels of sleepiness and cataplexy, highlighting the need for timely diagnosis in children based on their unique symptom profiles.
Objective: Narcolepsy is a sleep disorder characterized in humans by excessive daytime sleepiness and cataplexy. Greater than fifty percent of narcoleptic patients have an onset of symptoms prior to the age of 18. Current general agreement considers the loss of hypothalamic hypocretin (orexin) neurons as the direct cause of narcolepsy notably cataplexy.
View Article and Find Full Text PDFObjectives: The temporal association between sudden infant death syndrome (SIDS) and sleep suggests that the arousability from sleep provides a protective mechanism for survival. Recently, the hypocretin system, which promotes wakefulness, has been implicated in SIDS, since it has been reported that SIDS victims have fewer hypocretin neurons than infants who have died from other causes. To understand the role of hypocretin in SIDS, it is essential to better understand how this system matures.
View Article and Find Full Text PDFThe objective of this study was to evaluate the levels of plasma bicarbonate levels in narcoleptic children. Clinical, electrophysiological data and bicarbonate levels were evaluated retrospectively in children seen in our paediatric national reference centre for hypersomnia. The cohort included 23 control subjects (11.
View Article and Find Full Text PDFStudy Objectives: To evaluate the frequency, severity, and associations of symptoms of attention-deficit/hyperactivity disorder (ADHD) in children with narcolepsy with and without cataplexy.
Design: Cross-sectional survey.
Settings: Four French national reference centers for narcolepsy.
Objectives: We aimed to evaluate depressive feelings and their correlations in children and adolescents with narcolepsy collected in national reference centers for narcolepsy.
Methods: We compared clinical and sleep characteristics of patients with and without depressive symptoms evaluated on the Children's Depression Inventory (CDI).
Results: Our study sample included 88 children (44 boys; 44 de novo patients) with a mean age of 11.
Aims: To evaluate the impact of obesity on clinical and sleep characteristics in a population of narcoleptic children.
Methods: Data from the children diagnosed with idiopathic narcolepsy in the National Reference Centers for Narcolepsy were collected between 2008 and 2011. Clinical and electrophysiological characteristics were compared between obese (body mass index [BMI] greater than P97) and nonobese children.