Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome: A Case Report.

Group A (GAS), particularly (), is a significant human pathogen responsible for infections often ranging from mild superficial conditions to severe, life-threatening diseases like necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS). This case report details the rapid deterioration of a previously healthy 49-year-old woman who presented with localized symptoms in her left thigh, later escalating to septic shock and multi-organ failure related to GAS infection. Initial evaluations indicated significant inflammation and acute kidney injury, prompting broad-spectrum antibiotic treatment.

Pharmacodynamics of Voriconazole for Invasive Pulmonary Scedosporiosis.

is a medically important fungal pathogen that causes a wide range of infections in humans. There are relatively few antifungal agents that are active against spp. Little is known about the pharmacodynamics of voriconazole against Both static and dynamic models of invasive scedosporiosis were developed.

Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by Aspergillus flavus.

Background: Aspergillus flavus is one of the most common agents of invasive aspergillosis and is associated with high mortality. The orotomides are a new class of antifungal agents with a novel mechanism of action. An understanding of the pharmacodynamics (PD) of the lead compound F901318 is required to plan safe and effective regimens for clinical use.

Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients.

azole resistance has emerged as a global health problem. We evaluated the antifungal susceptibility of 221 clinical isolates according to CLSI guidelines. Sixty-one isolates exhibiting MICs at the epidemiological cutoff value (ECV) for itraconazole or above the ECV for any triazole were checked for mutations.