Publications by authors named "Clara K T Koh"
Signal transduction induced by chimeric antigen receptors (CARs) is generally believed to rely on the activity of the SRC family kinase (SFK) LCK, as is the case with T cell receptor (TCR) signaling. Here, we show that CAR signaling occurs in the absence of LCK. This LCK-independent signaling requires the related SFK FYN and a CD28 intracellular domain within the CAR.
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- * The research found that NUF2 is significantly overexpressed in 23 of the 31 cancer types analyzed and is associated with advanced tumor stages and poorer survival rates for patients.
- * In experiments involving hepatocellular carcinoma (HCC), silencing NUF2 in cell lines resulted in reduced tumor growth and invasiveness, indicating its potential role in cancer progression and the need for further investigation.