Cultivating Innovative Pragmatic Cluster-Randomized Registry Trials Embedded in Hemodialysis Care: Workshop Proceedings From 2018.

Hemodialysis is a life-sustaining treatment for persons with kidney failure. However, those on hemodialysis still face a poor quality of life and a short life expectancy. High-quality research evidence from large randomized controlled trials is needed to identify interventions that improve the experiences, outcomes, and health care of persons receiving hemodialysis.

Intradialytic exercise preconditioning: an exploratory study on the effect on myocardial stunning.

Background: Exercise preconditioning provides immediate protection against cardiac ischemia in clinical/preclinical studies in subjects without chronic kidney disease. In individuals requiring renal replacement therapy, hemodialysis (HD) results in significant circulatory stress, causing acute ischemia with resultant recurrent and cumulative cardiac injury (myocardial stunning). Intradialytic exercise (IDE) has been utilized to improve functional status in individuals receiving HD.

Impact of Exercise Counseling on Physical Function in Chronic Kidney Disease: An Observational Study.

Background: Individuals with chronic kidney disease (CKD) have low levels of physical activity and physical function. Although guidelines endorse exercise counseling for individuals with CKD, it is not yet part of routine care.

Objective: We investigated the effect of attending a real-life exercise counseling clinic (ECC) on physical function in individuals with CKD.

Frailty and physical function in chronic kidney disease: the CanFIT study.

Background: Frailty, a manifestation of unsuccessful aging, is highly prevalent in people with chronic kidney disease (CKD) and is associated with comorbid conditions in cross-sectional studies. Longitudinal studies investigating the progression of frailty in those with advanced non-dialysis CKD are lacking.

Objectives: Canadian Frailty Observation and Interventions Trial (CanFIT).

Association of frailty and physical function in patients with non-dialysis CKD: a systematic review.

Background: Frailty is a condition characterized by a decline in physical function and functional capacity. Common symptoms of frailty, such as weakness and exhaustion, are prevalent in patients with chronic kidney disease (CKD). The increased vulnerability of frail patients with coexisting CKD may place them at a heightened risk of encountering additional health complications.

Regular physical activity and exercise therapy in end-stage renal disease: how should we move forward?

The many benefits of physical activity in the general population are well accepted. A growing body of evidence in patients with end-stage renal disease (ESRD) demonstrates improvements to aerobic fitness and physical function with exercise therapy. This review outlines the major clinical findings associated with exercise training in ESRD, with a focus on survival and morbidity.