[Immune response and gene therapy with adenoassociated viral vectors].

In recent years, gene therapy has been positioned as a real and safe option in the development of therapeutic alternatives for the cure and prevention of different diseases. It consists in the insertion of genetic material in a defective tissue or cell, through the use of a vector. There are several considerations for selecting the most appropriate vector, including the potential for binding and entry to the target cell, the ability of the genetic material to transfer to the nucleus, the ability to express the insert, and the absence of toxicity.

Polymorphisms of the lipoprotein lipase gene as genetic markers for stroke in colombian population: a case control study.

Objective: To analyze if there is an association between the presence of polymorphisms in the gene (rs320, rs285 and rs328) with development of acute ischemic stroke in Colombian population.

Methods: In a case control design, 133 acute ischemic stroke patients (clinical diagnosis and x-ray CT) and 269 subjects without stroke as controls were studied. PCR -RFLP technique was used to detect rs320, rs285 and rs328 polymorphisms in the LPL gene.