Publications by authors named "Clara Hellberg"
Objectives: Antihistamines have been reported to be linked with less pain in osteoarthritis. We aimed to estimate associations between antihistamine use and three outcomes: prevalent osteoarthritis, current joint pain, and developing osteoarthritis.
Methods: We included 25 003 participants of EpiHealth - a cohort of persons aged 45 to 75 from Malmö/Uppsala in Sweden.
Article Synopsis
- The study investigates the relationship between body mass index (BMI) and Parkinson's disease (PD) using a method called Mendelian randomization to determine if higher genetically predicted BMI is linked to a lower incidence of PD.
- Researchers analyzed genetic data from large groups of individuals, including over 800,000 for BMI and nearly 29,000 for PD, focusing on factors like age, disease duration, and gender to examine the associations.
- Results indicated an inverse relationship between genetically predicted BMI and PD, particularly among younger participants and women, suggesting that lower BMI may be associated with a higher risk of developing Parkinson's disease.
Article Synopsis
- The study investigates the long-term effects of ACL injuries treated nonoperatively on knee function, symptoms, activity levels, and the incidence of osteoarthritis (OA) in a cohort of 100 patients over 30 years.
- Results show that while many patients retained decent functional scores, a significant portion developed radiographic evidence of OA (75%), yet only 38% experienced symptoms related to it.
- About half of the participants had meniscal surgeries, and 29% later underwent ACL reconstruction for instability, highlighting ongoing issues even after initial nonoperative treatment.
Aim: To investigate temporal trends in primary care visits, physiotherapy visits, dispensed non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in knee osteoarthritis (OA) patients who have and have not undergone knee replacement.
Methods: We analysed 5665 OA patients from the Skåne Healthcare Register, Sweden, who underwent knee replacement between 2015 and 2019. Controls were OA patients without knee replacement, matched 1:1 by sex, age, time and healthcare level of initial OA diagnosis, and assigned a pseudo-index date corresponding to their case's knee replacement date.
Purpose: (i) To report the prevalence of participants to a first-line intervention for OA in Sweden using over-the-counter (OTC) and/or prescribed NSAIDs; (ii) To estimate the accuracy of dispensed prescriptions of NSAIDs recorded in a Swedish health-care register to capture the use of NSAID considering clinician-report as reference standard.
Methods: Register-based study. We used data from OA individuals who participated in the Swedish first-line intervention recorded in the Swedish Osteoarthritis Register (SOAR).
Objective: To compare the prevalence and timing of knee surgery (including meniscal, ligamentous, synovial, and osteotomy) in the 10 years prior to primary total knee replacement (TKR) between England and Sweden.
Methods: This was a population-based, case-control study within England and southern Sweden using electronic health care databases. Patients underwent primary TKR between 2015 and 2019.
Article Synopsis
- - This study investigates the genetic factors influencing the age at onset (AAO) of Parkinson's disease (PD), aiming to address the inconsistencies in previous research and validate findings through a meta-analysis of diverse populations.
- - The meta-analysis combined data from the COURAGE-PD Consortium, which included over 8,500 patients primarily of European origin, and the International Parkinson Disease Genomics Consortium, reaching a total of nearly 26,000 participants.
- - The research confirmed a known genetic variant associated with PD AAO and discovered two genome-wide significant signals on chromosome 4, contributing new insights into the genetic basis of the disease's onset.
Article Synopsis
- Previous studies suggested that dairy intake may increase the risk of Parkinson's disease (PD), especially in men, but the nature of this relationship was unclear.
- This research used genetic data to investigate the link between dairy consumption and PD through a method called Mendelian randomization, involving nearly 10,000 patients and 8,000 controls.
- The results indicated that genetically predicted higher dairy intake is associated with an increased risk of PD, particularly in men, providing evidence for a possible causal relationship.
Article Synopsis
- The study investigates how lifestyle factors like smoking, alcohol, and coffee consumption relate to Parkinson's disease (PD), using a genetic approach to avoid potential biases in causation.* -
- Findings indicate that smoking is significantly associated with a lower risk of developing PD, while no such associations were found for alcohol or coffee consumption, though there is a suggestion that genetic vulnerability to PD might increase alcohol drinking.* -
- The research concludes that the protective effect of smoking on PD is likely genuine and not influenced by reverse causation or other biases; however, the data on alcohol and coffee remains inconclusive due to limited power.*
Nationwide prevalence of primary dystonia, progressive ataxia and hereditary spastic paraplegia.
Parkinsonism Relat Disord
December 2019
Objective: To determine the nationwide prevalence of primary dystonia, ataxia and hereditary spastic paraplegia (HSP) in Sweden.
Methods: We extracted data on all patients who were registered in The National Patient Register (NPR) in Sweden (population 9.64 million) at least twice during five consecutive years with a diagnosis of primary dystonia, ataxia or HSP.