Publications by authors named "Clara Garcia-Mateos"
Article Synopsis
- Chiral nitrogen-containing compounds are essential in various industries, but their synthesis can be challenging due to a vast range of chemical possibilities.
- This research details a selective method to create 3,3-diarylallyl phthalimides, which, when treated with iridium catalysts, transform into 3,3-diarylpropyl amines with very high enantioselectivity (98-99% ee).
- The study highlights the role of alkene purity in achieving high enantioselectivity and illustrates how the resulting chiral propylamines can be used to make important bioactive drugs like tolterodine and tolpropamine.
Chiral compounds containing nitrogen heteroatoms are fundamental substances for the chemical, pharmaceutical and agrochemical industries. However, the preparation of some of these interesting scaffolds is still underdeveloped. Herein we present the synthesis of a family of P-stereogenic phosphinooxazoline iridium catalysts from L-threonine methyl ester and their use in the asymmetric hydrogenation of N-Boc-2,3-diarylallyl amines, achieving very high enantioselectivity.
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