Publications by authors named "Clara G Altomare"
Article Synopsis
- Despite existing vaccines, influenza continues to cause significant illness and death globally due to the virus's ability to mutate and evade immune responses.
- Current vaccines focus on the less stable head domain of the hemagglutinin (HA) protein, while targeting the more conserved stalk domain could provide better protection, though traditional vaccines generate low levels of antistalk antibodies.
- Research shows that using nanoparticles to present HA in an inverted orientation significantly increases antistalk antibody production and broadens the immune response, leading to better outcomes in mice, suggesting a new approach for developing effective vaccines against influenza and other potential pandemics.
Article Synopsis
- The study investigates how antibodies from infection or vaccination interact with viruses, specifically focusing on a monoclonal antibody (mAb) that was triggered by an mRNA vaccine against SARS-CoV-2.
- Researchers used electron cryomicroscopy to analyze the mAb's structure in conjunction with the virus's spike glycoprotein, revealing a new neutralizing site on the protein's N-terminal domain (NTD).
- The antibody, labeled PVI.V6-14, is noted for being unmutated and able to bind effectively to various viral variants, showing its potential to inform vaccine design by targeting a stable, conserved epitope.
Article Synopsis
- The study investigates the adaptive immune response by examining the naive B cell repertoire's ability to recognize and target SARS-CoV-2, focusing on the receptor binding domain (RBD).
- Researchers isolated naive B cells from eight human donors and used single-cell B cell receptor sequencing to analyze their diversity and specificity against various SARS-CoV-2 variants and related coronaviruses.
- Structural analysis revealed that certain naive antibodies could effectively signal B cell activation and, after optimization, showed strong neutralization capabilities against SARS-CoV-2, potentially aiding in the development of broad coronavirus vaccines.
Article Synopsis
- * Analysis of monoclonal antibodies from mRNA vaccine-elicited B cells revealed that while most neutralized the original WA1/2020 D614G strain, their effectiveness varied against variants like B.1.617.2 and B.1.351.
- * The monoclonal antibody 2C08 was particularly effective, reducing lung viral loads in hamsters and was found in a significant portion of individuals vaccinated or infected with SARS-CoV-2, indicating potential for wider application in combating variants.
Article Synopsis
- * Researchers isolated naive B cells from seronegative donors and analyzed their gene usage, finding a diverse range that could help in targeting the virus effectively.
- * They discovered that both naive and engineered antibodies could neutralize SARS-CoV-2 and suggest that understanding these B cells could aid in creating universal vaccines against coronaviruses.
The piriform cortex (PCX) is the largest component of the olfactory cortex and is hypothesized to be the locus of odor object formation. The distributed odorant representation found in PCX contrasts sharply with the topographical representation seen in other primary sensory cortices, making it difficult to test this view. Recent work in PCX has focused on functional characteristics of these distributed afferent and association fiber systems.
View Article and Find Full Text PDFObjective: We present a systematic review and meta-analysis of the frequency, consequences, and treatment of stent loss during percutaneous coronary intervention (PCI).
Background: Stent loss during PCI has received limited study.
Methods: We conducted a meta-analysis of 18 case series and 45 case reports published between 1991 and 2012 on stent loss during PCI.