Publications by authors named "Clara E Correa-Soto"
In a previous publication, we determined the kinetics and equilibrium for the sorption of propylparaben to polyvinyl chloride (PVC). In this work, we extend that study to investigate the sorption of methylparaben and propylparaben on tubing surfaces made of PVC and fluorinated ethylene propylene (FEP) using molecular dynamics simulations. The simulations suggest the mechanism of sorption to be adsorption.
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- * The adsorption process is analyzed using a pseudo-second order model, indicating that the rate of adsorption increases with higher concentrations of propylparaben.
- * The adsorption isotherm data is best represented by the Freundlich and Temkin models, suggesting a multi-layer process, which helps in understanding compatibility between pharmaceutical components and their packaging materials.
Purpose: Plasticizers are commonly used in the preparation of amorphous solid dispersions (ASDs) with the main goal of aiding processability; however, to the best of our knowledge, the impact of plasticizers on drug release has not been explored. The goal of this study was to evaluate diverse plasticizers, including glycerol and citrate derivatives, as additives to increase the drug loading where good drug release could be achieved from copovidone (PVPVA)-based dispersions, focusing on high glass transition (T) drugs, atazanavir (ATZ) and ledipasvir (LED).
Methods: ASDs were prepared using the high T compounds, atazanavir (ATZ) and ledipasvir (LED), as model drugs.
Amorphous solid dispersion formulations (ASD) are increasingly being used as a formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations of ASDs, in particular for high glass transition temperature (T) compounds, is the drug loading threshold (termed the limit of congruency, LoC) below which rapid, complete and congruent release of drug and polymer is achieved. In this study, several ionic and non-ionic surfactants were added to atazanavir-copovidone ASDs with the main goal of increasing the limit of congruency.
View Article and Find Full Text PDFPurpose: Surfactants are increasingly being added to amorphous solid dispersion (ASDs) formulations to enhance processability and release performance. The goal of the current work was to investigate the impact of cationic, anionic and non-ionic surfactants on the rate and extent of clopidogrel (CPD) release from copovidone-based ASDs.
Methods: CPD release was evaluated for ASDs with different drug loadings using a surface normalized intrinsic dissolution apparatus.