Publications by authors named "Clara Clipet-Jensen"
Article Synopsis
- BCG (Bacillus Calmette-Guérin) has shown non-specific immune benefits against infections, and this study investigates its effects in older adults in a TB-endemic area.
- A single-blinded trial in Guinea-Bissau involved 40 adults over 50, with half receiving BCG and the other half a placebo, measuring cytokine production after vaccination.
- Results showed that BCG improved immune responses, particularly in those previously exposed to TB, indicating its potential for enhancing immunity in older populations and warranting further research.
Vaccines may alter the ability to combat infections unrelated to the target disease, i.e. have "nonspecific effects.
View Article and Find Full Text PDFBackground: Childhood is a sensitive period with rapid brain development and physiological growth, and adverse events in childhood might interfere with these processes and have long-lasting effects on health. In this study, we aimed to describe trajectories of adverse childhood experiences and relate these to overall and cause-specific mortality in early adult life.
Methods: For this population-based cohort study, we used unselected annually updated data from Danish nationwide registers covering more than 1 million children born between 1980 and 1998.
Background: Manual white blood cell (WBC) differential counts as a predictor for neonatal sepsis development in a low-resource setting have not been thoroughly evaluated. We hypothesized that manual differentiation (specifically immature:total [I:T] neutrophil ratios) would be feasible and useful as an adjunct to predict early-onset neonatal sepsis (EONS). Secondarily, we hypothesized that vaccination with bacillus Calmette-Guérin (BCG) and oral polio vaccine (OPV) could alter WBC differential counts and thus might reduce its predictive performance.
View Article and Find Full Text PDFBackground: Due to delays in vaccinations, diphtheria-tetanus-whole-cell-pertussis (DTP) is often given with or after measles vaccine (MV)-out of sequence. We reanalyzed data from Matlab, Bangladesh, to examine how administration of MV and DTP out-of-sequence was associated with child survival.
Methods: In sum, 36 650 children born between 1986 and 1999 were followed with registration of vaccinations and survival.