Crystal structure of Cd,Zn metallothionein.

The crystal structure of Cd,Zn metallothionein isoform II from rat liver has been determined using the anomalous scattering data from five Cd in the native protein. The structure of a 4Cd cluster was solved by direct methods. A 2.

Crystal structure of Cd,Zn metallothionein.

The anomalous scattering data from five Cd in the native protein were used to determine the crystal structure of cadmium, zinc (Cd,Zn) metallothionein isoform II from rat liver. The structure of a 4-Cd cluster was solved by direct methods. A 2.

Arachidonic acid metabolites and small airways disease in non-smoking sarcoidosis patients.

The present study was designed to assess the occurrence of small airways disease (SAD) in non-smoking sarcoidosis patients by pulmonary function measurement; and to investigate the possible mechanisms of SAD by measuring the in vitro production of arachidonic acid metabolites (PGE2 and LTB4) by peripheral blood mononucleocytes from sarcoidosis patients. SAD did in fact occur in 15 of the 32 sarcoid patients studied. The increase in LTB4 and decrease in PGE2 observed in SAD patients could imply a causative role for these arachidonic acid metabolites in SAD.

Cellulitis in complicated pneumococcal pneumonia.

Serious complications of pneumococcal pneumonia have become uncommon. This has been attributed to decline in pneumococcal infection (van Roy et al. 1971; Foy et al.

Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure.

We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+.

Long-term domiciliary oxygen therapy in cor pulmonale complicating chronic bronchitis and emphysema.

Ten patients with cor pulmonale complicating severe chronic bronchitis and emphysema have been treated with 2 litres/min of oxygen for prolonged periods in the day, at home, over 12 to 62 months. Two patients died after 12 and 36 months of treatment. Pulmonary arterial pressure was reduced in seven patients, and red cell mass in eight, when the oxygen was given for over 15 hours in the day.

Maximal exercise studies in Scottish athletes.

We have studied maximal oxygen uptake, maximal heart rate, maximal exercise ventilation and the ventilatory response to exercise in 24 male and 14 female Scottish athletes. The values for maximal oxygen uptake are similar to those reported in other international studies. In eight athletes repeat measurements of maximal oxygen uptake 7-11 months after the initial study showed no change from the initial values.

Effect of intravenous infusion of salbutamol on ventilatory response to carbon dioxide and hypoxia and on heart rate and plasma potassium in normal men.

Intravenous infusion of salbutamol 10 mug/min in seven healthy subjects significantly increased their ventilatory responses to inhaled CO2 in both hypoxia and hyperoxia. These changes in chemical control of breathing are unlikely to be significant when the drug is used in severe asthma but may benefit patients with acute exacerbations of chronic ventilatory failure. The infusion also increased heart rate, which was most pronounced when hypoxia was combined with hypercapnia.

Arterial catecholamines in hypoxic exercise in man.

1. We measured the minute ventilation and arterial blood catecholamine concentrations in four normal men standing and at two levels of moderate treadmill exercise breathing 14% oxygen or air. 2.