Focal duodenal necrosis in chickens: attempts to reproduce the disease experimentally and diagnostic considerations.

Focal duodenal necrosis (FDN) is an intestinal disease of egg-layer chickens characterized by multifocal necrosis of the duodenal loop and proximal jejunum. Affected flocks usually have decreased egg weights and drops in egg production. Previous studies have associated this condition with infection.

The Contribution of Coinfection and Intestinal Inflammation to Cecal Colonization and Systemic Spread of Typhimurium Deficient in Tetrathionate Reductase or Type III Secretion Systems Pathogenicity Island 1 or 2.

Intestinal inflammation may provide a growth advantage for and enhance its systemic spread in chickens. triggers intestinal inflammation in the host by using type III secretion systems (T3SS) and produces the inflammatory end product tetrathionate. In mice, tetrathionate respiration confers a growth advantage for Typhimurium over the competitive microbiome in the inflamed intestine.