Spinal cord stimulation for the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials.

Background: Spinal Cord Stimulation (SCS) is a widely recognized treatment for Complex Regional Pain Syndrome (CRPS), particularly in cases where traditional methods are ineffective. This paper systematically reviews randomized controlled trials to analyze the efficacy of SCS, as well as Dorsal Root Ganglion (DRG) Stimulation in treating CRPS, focusing on its long-term effectiveness.

Methods: This systematic review focused exclusively on randomized controlled trials to assess a primary outcome of improvement in pain symptoms in patients diagnosed with CRPS.

Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis.

The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, which limits the development of effective therapies. In this work, we show that BCCs in mice can invade the LM by abluminal migration along blood vessels that connect vertebral or calvarial bone marrow and meninges, bypassing the blood-brain barrier. This process is dependent on BCC engagement with vascular basement membrane laminin through expression of the neuronal pathfinding molecule integrin α6.

Translating Catalyst-Polymer Composites from Liquid to Gas-Fed CO Electrolysis: A CoPc-P4VP Case Study.

The electrochemical CO reduction reaction (CORR) in gas-fed flow electrolyzers using gas diffusion electrodes (GDEs) generates industrially relevant activities and provides a promising approach for carbon recycling. Developing effective catalyst systems on GDEs is critical for achieving high activities. Catalyst-polymer composites (CPCs) formed between immobilized molecular catalysts and coordinating polymers exhibit positive synergies for the enhancement of CORR activity.

Spinal cord stimulator malfunction as a result of lead fracture: a case report.

Spinal cord stimulation is a successful and thoroughly documented procedure in treating chronic refractory pain. Complications are rare and usually mild, but hardware complications such as electrode dysfunction have been shown to be detrimental in treatment efficacy and patient outcome. We report a case in which a patient diagnosed with complex regional pain syndrome underwent spinal cord stimulation for pain management and experienced lead migration and fracture, resulting in loss of paresthesia and increased pain.