Publications by authors named "Claire Wingert"
Article Synopsis
- Researchers rediscovered the intracellular bacterium Cm, historically linked to severe pneumonia in mice, in research mouse colonies, noting its moderate prevalence.
- They observed clinical disease in genetically engineered mouse strains with impaired immune responses, presenting symptoms like poor condition and hunched posture, along with histopathological evidence of Cm in various tissues.
- The study suggests that Cm could negatively impact research validity, underscoring the need to exclude this bacterium from mouse colonies used in scientific studies.
Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features, including antigen specificity, clonal expansion and memory. As such, NK cells share many transcriptional and epigenetic programs with their adaptive CD8 T cell siblings. Various signals ranging from antigen, co-stimulation and proinflammatory cytokines are required for optimal NK cell responses in mice and humans during virus infection; however, the integration of these signals remains unclear.
View Article and Find Full Text PDFInflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and how human infections and associated inflammation can form innate immune memory in hematopoietic stem and progenitor cells (HSPC) has remained unclear. We found that circulating HSPC, enriched from peripheral blood, captured the diversity of bone marrow HSPC, enabling investigation of their epigenomic reprogramming following coronavirus disease 2019 (COVID-19).
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