Publications by authors named "Claire Rodriguez"
Article Synopsis
- Scientists studied how the sympathetic nervous system affects patients with congenital long QT syndrome (LQTS), a heart condition caused by gene mutations.
- They compared brain scans of 11 LQTS patients to 8 healthy people using a special imaging technique.
- Results showed that patients had more areas with lower nerve function in the heart, especially in those with more severe symptoms, suggesting that the sympathetic nervous system can make the disease worse.
Due to the high incidence of breast cancer and associated mortality rate,the development of an effective vaccine may be beneficial for the prevention or adjuvant treatment of this malignancy. We have constructed a novel breast cancer vaccine, Bacillus Calmette-Guérin (BCG)-hIL2MUC1, that consists of BCG and expresses a truncated form of MUC1 and human interleukin (IL)-2. In vitro analysis of the BCG-hIL2MUC1 construct confirmed coexpression of MUC1 and human IL-2.
View Article and Find Full Text PDFPreservation of ischemia and isoflurane-induced preconditioning after brain death in rabbit hearts.
Am J Physiol Heart Circ Physiol
November 2002
We sought to determine whether brain death-induced catecholamine release preconditions the heart, and if not, whether it precludes further protection by repetitive ischemia or isoflurane. Anesthetized rabbits underwent 30 min of coronary occlusion and 4 h of reperfusion. The effect on infarct size of either no intervention (controls), ischemic preconditioning (IPC), or isoflurane inhalation (Iso) was evaluated with or without previous brain death (BD) induced by subdural balloon inflation.
View Article and Find Full Text PDFA comparative study of the most widely used solutions for cardiac graft preservation during hypothermia.
J Heart Lung Transplant
September 2002
Background: Reports conflict on the benefits of preservative solutions. We investigated the efficacy of the most widely used cardioplegic solutions by comparing extracellular solutions such as Celsior solution, St. Thomas Hospital solutions 1 and 2 (STH-1, STH-2), the modified University of Wisconsin solution (UW-1), Lyon Preservation solution (LYPS) from our laboratory, and intracellular solutions such as standard University of Wisconsin solution (UW), Bretschneider solution (HTK), Stanford solution (STF), and Euro-Collins solution (EC).
View Article and Find Full Text PDFAn optimal experimental design for the development of preservative heart solutions.
J Heart Lung Transplant
February 2002
Background: The aim of this study was to determine the optimal composition of a new medium for long-term hypothermic heart preservation.
Methods: The independent effects of 19 compounds were evaluated using an in vitro porcine model. Tissue viability was assessed by measuring the reduction of methyltetrazolium salt, oxygen consumption and energetic compound levels on myocardial biopsies after 24-, 48- or 72-hour incubation periods.